Molecular & Cellular Biology Graduate Program, Department of Biology, University of Washington, Seattle, Washington.
Department of Biology, University of Washington, Seattle, Washington.
J Biol Rhythms. 2024 Oct;39(5):502-507. doi: 10.1177/07487304241262918. Epub 2024 Jul 31.
There is growing interest in developing artificial lighting that stimulates intrinsically photosensitive retinal ganglion cells (ipRGCs) to entrain circadian rhythms to improve mood, sleep, and health. Efforts have focused on stimulating the intrinsic photopigment, melanopsin; however, specialized color vision circuits have been elucidated in the primate retina that transmit blue-yellow cone-opponent signals to ipRGCs. We designed a light that stimulates color-opponent inputs to ipRGCs by temporally alternating short- and long-wavelength components that strongly modulate short-wavelength sensitive (S) cones. Two-hour exposure to this S-cone modulating light produced an average circadian phase advance of 1 h and 20 min in 6 subjects (mean age = 30 years) compared to no phase advance for the subjects after exposure to a 500 lux white light equated for melanopsin effectiveness. These results are promising for developing artificial lighting that is highly effective in controlling circadian rhythms by invisibly modulating cone-opponent circuits.
人们越来越感兴趣的是开发能够刺激内在感光视网膜神经节细胞（ipRGCs）的人工照明，以调整生理节律，改善情绪、睡眠和健康。人们一直专注于刺激内在光色素视黑质；然而，在灵长类动物视网膜中已经阐明了专门的彩色视觉回路，这些回路将蓝-黄视锥细胞对抗信号传递给 ipRGCs。我们设计了一种通过暂时交替短波长和长波长成分来刺激 ipRGCs 的色觉对抗输入的光，这种光强烈调节短波长敏感（S）视锥细胞。与接受相当于视黑质效力的 500 勒克斯白光照射的受试者相比，6 名受试者（平均年龄为 30 岁）接受这种 S 锥光调制光照射两小时，平均生理节律提前 1 小时 20 分钟。这些结果很有希望，因为通过对视锥细胞对抗电路进行隐形调节，可以开发出非常有效的人工照明来控制生理节律。
