Zhang Xinge Diana, Teng Claudia, Bai Xuefei, Teng Joyce, Chilukuri Suneel, Lewis Amy, Gold Michael H
School of Applied Sciences and Engineering, Harvard University, Cambridge, Massachusetts, USA.
B.A.I. Biosciences, Inc., Cambridge, Massachusetts, USA.
J Cosmet Dermatol. 2024 Dec;23(12):4043-4050. doi: 10.1111/jocd.16508. Epub 2024 Jul 31.
Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond-Augmented Zinc Oxide (ND-ZnO) technology combines zinc oxide with diamond particles in a unique core-shell structure, offering a multifaceted approach to overall skin health.
This study evaluates the efficacy of ND-ZnO in promoting human dermal fibroblast migration and growth, enhancing total collagen synthesis, and improving transdermal delivery of active ingredients as a daily comprehensive skin regeneration topical therapy.
PATIENTS/METHODS: In vitro assays assessed wound healing, collagen production, and skin absorption. Human Dermal Fibroblasts (HDFs) were used in scratch wound assays. Collagen synthesis was quantified using enzyme-linked immunosorbent assays (ELISA). Permeation tests were performed on reconstructed human epidermal tissues to evaluate niacinamide absorption. Clinical case studies validated ND-ZnO efficacy in post-CO laser treatments and Actinic Keratosis removal recovery.
ND-ZnO increased HDF migration by 198% compared to controls. Collagen synthesis assays showed a 71.3% restoration of collagen production in aged HDFs. Skin permeation studies revealed a 203% increase in niacinamide skin absorption with ND-ZnO. Clinical case studies demonstrated faster and more effective healing post-ablative CO₂ laser and significant improvements in Actinic Keratosis recovery.
ND-ZnO technology enhances wound healing, collagen synthesis, and active ingredient delivery, offering substantial benefits for daily skin regeneration and other dermatological applications. This innovative approach holds promise for advancing dermatological therapeutics, providing comprehensive skin care solutions that address both protective and regenerative needs.
皮肤病治疗领域的最新进展凸显了对促进皮肤再生和愈合的治疗方法的需求。钻石增强氧化锌（ND-ZnO）技术将氧化锌与钻石颗粒以独特的核壳结构相结合，为整体皮肤健康提供了多方面的解决方案。
本研究评估ND-ZnO作为一种日常全面的皮肤再生局部疗法，在促进人真皮成纤维细胞迁移和生长、增强总胶原蛋白合成以及改善活性成分经皮递送方面的功效。
患者/方法：体外试验评估伤口愈合、胶原蛋白生成和皮肤吸收情况。在划痕伤口试验中使用人真皮成纤维细胞（HDFs）。使用酶联免疫吸附测定（ELISA）对胶原蛋白合成进行定量。在重建的人表皮组织上进行渗透试验，以评估烟酰胺的吸收情况。临床病例研究验证了ND-ZnO在二氧化碳激光治疗后和光化性角化病去除恢复中的疗效。
与对照组相比，ND-ZnO使HDF迁移增加了198%。胶原蛋白合成试验显示，老年HDFs中的胶原蛋白生成恢复了71.3%。皮肤渗透研究表明，使用ND-ZnO后烟酰胺的皮肤吸收增加了203%。临床病例研究表明，剥脱性二氧化碳激光治疗后愈合更快、更有效，光化性角化病的恢复有显著改善。
ND-ZnO技术可促进伤口愈合、胶原蛋白合成和活性成分递送，为日常皮肤再生和其他皮肤病应用带来显著益处。这种创新方法有望推动皮肤病治疗的发展，提供满足保护和再生需求的全面皮肤护理解决方案。
