Zhou Jian, Dong Chen, Shu Qiuju, Chen Yang, Wang Qing, Wang Dandan, Ma Ge
Savaid Stomatology School, Hangzhou Medical College, Hangzhou, China.
Department of Prosthodontics, Xi'an Savaid Stomatology Hospital, Xi'an, China.
Front Med (Lausanne). 2022 Jul 22;9:947649. doi: 10.3389/fmed.2022.947649. eCollection 2022.
Increasing attention to skin regeneration has rapidly broadened research on the topic. However, no bibliometric analysis of the field's research trends has yet been conducted. In response to this research gap, this study analyzed the publication patterns and progress of skin regeneration research worldwide using a bibliometric analysis of 1,471 papers comprising 1,227 (83.4%) original articles and 244 (16.6%) reviews sourced from a Web of Science search. Publication distribution was analyzed by country/region, institution, journal, and author. The frequency of keywords was assessed to prepare a bibliometric map of the development trends in skin regeneration research. China and the United States were the most productive countries in the field: China had the greatest number of publications at 433 (29.4%) and the United States had the highest H-index ranking (59 with 15,373 citations or 31.9%). Author keywords were classified into four clusters: stem cell, biomaterial, tissue engineering, and wound dressing. "Stem cells," "chitosan," "tissue engineering," and "wound dressings" were the most frequent keywords in each cluster; therefore, they reflected the field's current focus areas. "Immunomodulation," "aloe vera," "extracellular vesicles," "injectable hydrogel," and "three-dimensional (3D) bioprinting" were relatively new keywords, indicating that biomaterials for skin regeneration and 3D bioprinting are promising research hotspots in the field. Moreover, clinical studies on new dressings and techniques to accelerate skin regeneration deserve more attention. By uncovering current and future research hotspots, this analysis offers insights that may be useful for both new and experienced scholars striving to expand research and innovation in the field of skin regeneration.
对皮肤再生的日益关注迅速拓宽了该主题的研究范围。然而，尚未对该领域的研究趋势进行文献计量分析。针对这一研究空白，本研究通过对1471篇论文进行文献计量分析，来分析全球皮肤再生研究的发表模式和进展，这些论文包括从Web of Science搜索中获取的1227篇（83.4%）原创文章和244篇（16.6%）综述。通过国家/地区、机构、期刊和作者对发表分布进行了分析。评估了关键词的出现频率，以绘制皮肤再生研究发展趋势的文献计量图。中国和美国是该领域产出最多的国家：中国的出版物数量最多，为433篇（29.4%），美国的H指数排名最高（59，被引次数为15373次，占31.9%）。作者关键词被分为四个聚类：干细胞、生物材料、组织工程和伤口敷料。“干细胞”“壳聚糖”“组织工程”和“伤口敷料”是每个聚类中出现频率最高的关键词；因此，它们反映了该领域当前的重点研究领域。“免疫调节”“芦荟”“细胞外囊泡”“可注射水凝胶”和“三维（3D）生物打印”是相对较新的关键词，表明用于皮肤再生的生物材料和3D生物打印是该领域有前景的研究热点。此外，关于加速皮肤再生的新敷料和技术的临床研究值得更多关注。通过揭示当前和未来的研究热点，本分析提供了一些见解，可能对致力于在皮肤再生领域拓展研究和创新的新老学者都有用。
