Department of Cancer AI and Digital Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea; Department of Family Medicine, National Cancer Center, Goyang, Korea.
Nutrition. 2024 Oct;126:112519. doi: 10.1016/j.nut.2024.112519. Epub 2024 Jun 12.
The recommended dietary allowance (RDA) for vitamin C differs greatly (40-110 mg/d) across countries. In addition, vitamin D deficiency is, effectively, a pandemic, with a prevalence of approximately 25% to 80% across countries according to the findings in the recent scientific literature. However, these phenomena are attributable to a serious error in the concept and definition of RDA, which was developed in 1941. The current definition of RDA is the average daily dietary nutrient intake level that is deemed sufficient to meet the nutrient requirements of almost all (97-98%) healthy individuals. This is an extremely high intake level for a specific nutrient affecting only a few individuals (the upper 2.5%) of the generally healthy population. The RDA should be redefined by investigating at which intake level of a specific nutrient the incidence of a specific disease or mortality increases or decreases based on prospective cohort studies.
各国推荐的膳食营养素供给量（RDA）差异很大（40-110mg/d）。此外，根据最近科学文献中的研究结果，维生素 D 缺乏实际上是一种全球性的流行病，其流行率约为 25%至 80%。然而，这些现象归因于 RDA 概念和定义中的一个严重错误，该错误是在 1941 年提出的。目前 RDA 的定义是被认为足以满足几乎所有（97-98%）健康个体的营养需求的平均每日膳食营养素摄入量水平。对于影响极少数个体（一般健康人群中通常占 2.5%）的特定营养素，这是一个极高的摄入量水平。RDA 应该通过前瞻性队列研究来重新定义，即在哪个特定营养素的摄入量水平上，特定疾病或死亡率的发生率增加或减少。
