Department of Restorative Dentistry, University of São Paulo (USP), School of Dentistry, Av. Prof Lineu Prestes 2227, São Paulo, SP, 05508-000, Brazil.
Material Science and Technology Center, Nuclear and Energy Research Institute (IPEN-CNEN), Av. Prof. Lineu Prestes 2242, São Paulo, SP 05508-000, Brazil.
J Dent. 2024 Oct;149:105273. doi: 10.1016/j.jdent.2024.105273. Epub 2024 Jul 29.
The present study aimed to synthesize toothpastes containing Beta- TriCalcium Phosphate (β-TCP) nanoparticles, functionalized with fluoride and tin, and test their ability to reduce erosive tooth wear (ETW).
Toothpastes were synthesized with the following active ingredients: 1100 ppm of fluoride (as sodium fluoride, F), 3500 ppm of tin (as stannous chloride, Sn), and 800 ppm of β-TCP (Sizes a - 20 nm; and b - 100 nm). Enamel specimens were randomly assigned into the following groups (n = 10): 1. Commercial toothpaste; 2. Placebo; 3 F; 4. F + β-TCP; 5. F + β-TCP; 6. F + Sn; 7. F + Sn + β-TCP and 8. F + Sn + β-TCP. Specimens were subjected to erosion-abrasion cycling. Surface loss (in µm) was measured by optical profilometry. Toothpastes pH and available F were also assessed.
Brushing with placebo toothpaste resulted in higher surface loss than brushing with F (p = 0.005) and F + β-TCP (p = 0.007); however, there was no difference between F and F + β-TCP (p = 1.00). Commercial toothpaste showed no difference from Placebo (p = 0.279). The groups F, F + β-TCP, F + β-TCP, F + Sn, F + Sn + β-TCP and F + Sn + β-TCP were not different from the commercial toothpaste (p > 0.05). Overall, the addition of β-TCP reduced the amount of available fluoride in the experimental toothpastes. The pH of toothpastes ranged from 4.97 to 6.49.
Although toothpaste containing β-TCP nanoparticles protected enamel against dental erosion-abrasion, this effect was not superior to the standard fluoride toothpaste (commercial). In addition, the functionalization of β-TCP nanoparticles with fluoride and tin did not enhance their protective effect.
Although β-TCP nanoparticles have some potential to control Erosive Tooth Wear, their incorporation into an experimental toothpaste appears to have a protective effect that is similar to a commercial fluoride toothpaste.
本研究旨在合成含有β-三钙磷酸盐（β-TCP）纳米粒子的牙膏，这些纳米粒子经过氟化物和锡的功能化处理，以测试其减少酸蚀性牙齿磨损（ETW）的能力。
使用以下活性成分合成牙膏：1100ppm 氟化物（以氟化钠，F 表示）、3500ppm 锡（以二氯化锡，Sn 表示）和 800ppm β-TCP（粒径分别为 a-20nm 和 b-100nm）。将牙釉质标本随机分为以下几组（n=10）：1. 市售牙膏；2. 安慰剂；3. F；4. F+β-TCP；5. F+β-TCP；6. F+Sn；7. F+Sn+β-TCP 和 8. F+Sn+β-TCP。标本进行酸蚀-磨损循环。通过光学轮廓仪测量表面损失（以 µm 计）。还评估了牙膏的 pH 值和可用氟化物。
用安慰剂牙膏刷牙导致的表面损失高于用 F（p=0.005）和 F+β-TCP（p=0.007）刷牙；然而，F 与 F+β-TCP 之间没有差异（p=1.00）。商业牙膏与安慰剂之间无差异（p=0.279）。F、F+β-TCP、F+β-TCP、F+Sn、F+Sn+β-TCP 和 F+Sn+β-TCP 组与市售牙膏之间无差异（p＞0.05）。总体而言，β-TCP 的添加减少了实验牙膏中可用氟化物的量。牙膏的 pH 值范围为 4.97 至 6.49。
尽管含有β-TCP 纳米粒子的牙膏能保护牙釉质免受酸蚀-磨损，但这种效果并不优于标准的氟化物牙膏（市售）。此外，β-TCP 纳米粒子经氟化物和锡功能化处理并未增强其保护作用。
尽管β-TCP 纳米粒子具有控制酸蚀性牙齿磨损的潜力，但将其纳入实验牙膏似乎具有与市售氟化物牙膏相似的保护作用。
