Universidad Católica de Santa María, Facultad de Ciencias Farmacéuticas, Bioquímicas y Biotecnológicas, Arequipa, Peru.
São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil.
Int J Biol Macromol. 2024 Oct;277(Pt 1):133831. doi: 10.1016/j.ijbiomac.2024.133831. Epub 2024 Jul 31.
Cellulose from bacteria is a high-purity biomaterial naturally produced by bacteria as part of their metabolic process. Although it inherently lacks antimicrobial activity, its modification with bioactive substances can significantly enhance its efficacy beyond that of the original compounds. This biomaterial features a unique ability to retain substantial quantities of liquids within its three-dimensional network, making it a prime candidate for biomedical applications. Versatile in its properties, it can be utilized across various industries. Previous research has highlighted its capacity to exhibit antimicrobial properties and to encapsulate nanostructured materials, thereby augmenting its antibacterial effectiveness. This review focuses on the use of cellulose from bacteria as a carrier for active compounds, specifically targeting antibacterial activity against drug-resistant strains. We explore its role in innovative bacterial cellulose-based systems, which present a promising solution for tackling bacterial resistance. This review aims to showcase the potential of bacterial cellulose in developing new devices and treatment strategies that address critical concerns in global health.
细菌纤维素是一种高纯度的生物材料，是细菌在代谢过程中自然产生的。虽然它本身没有抗菌活性，但通过与生物活性物质的修饰，可以显著提高其功效，超越原始化合物的效果。这种生物材料具有独特的能力，可以在其三维网络中保留大量的液体，使其成为生物医学应用的首选材料。它的性能多样，可以在各个行业中使用。以前的研究已经强调了它表现出抗菌性能和封装纳米结构材料的能力，从而增强了其抗菌效果。这篇综述重点介绍了细菌纤维素作为活性化合物载体的用途，特别是针对对抗耐药菌株的抗菌活性。我们探讨了它在创新的细菌纤维素基系统中的作用，该系统为解决细菌耐药性问题提供了有前途的解决方案。本综述旨在展示细菌纤维素在开发新设备和治疗策略方面的潜力，这些策略解决了全球健康领域的关键问题。
