Institute for Biomedical Sciences, 967 East Parkcenter Blvd, Ste 205, Boise, ID, 83706, USA.
Sci Rep. 2024 Jul 31;14(1):17621. doi: 10.1038/s41598-024-65979-1.
Plantar fasciitis is the most common cause of heel pain in adults with an overall prevalence of 0.85% in the adult population of the US, affecting over 2 million adults annually. Most current treatment modalities are not supported by sufficient evidence to recommend one particular strategy over another. Topical application of analgesics for soft tissue pain is well established, however the plantar fascia presents challenges in this regard due to thick skin, fibrotic tissue, and an often thickened fat pad. Sixty-two patients with plantar fasciitis were randomized to a placebo controlled trial testing the efficacy of a topical solution of plant terpenes containing camphor, menthol, eugenol, eucalyptol, and vanillin. Skin permeation of the mixture was enhanced with 15% dimethylsulfoxide (DMSO), 1% limonene, and rosemary oil. One ml of solution was applied topically twice daily, and pain scores evaluated on Day 0, Day 1, Day 3, and Day 10. Using the validated foot function index 78.1% of patients reported an 85% or greater decrease in their total pain score by day 10 while placebo treatment was without effect (One Way ANOVA, P < 0.01). This study adapts the treatment modality of topical analgesia for soft tissue pain to a problematic area of the body and shows therapeutic promise.ClinicalTrials.gov Identifier: NCT05467631.
足底筋膜炎是成年人足跟痛最常见的原因，在美国成年人中总体患病率为 0.85%，每年影响超过 200 万成年人。大多数当前的治疗方法没有足够的证据支持，无法推荐一种特定的策略优于另一种策略。局部应用镇痛药治疗软组织疼痛已有充分证据，但由于足底筋膜的皮肤较厚、组织纤维化以及脂肪垫常常增厚，在这方面存在挑战。62 例足底筋膜炎患者被随机分配到一项安慰剂对照试验中，该试验测试了一种含有樟脑、薄荷醇、丁香酚、桉树脑和香草醛的植物萜烯的局部溶液的疗效。混合物的皮肤渗透通过 15%二甲基亚砜（DMSO）、1%柠檬烯和迷迭香油增强。每天两次将 1 毫升溶液局部应用，在第 0、1、3 和 10 天评估疼痛评分。使用经过验证的足部功能指数，78.1%的患者报告他们的总疼痛评分在第 10 天减少了 85%或更多，而安慰剂治疗没有效果（单因素方差分析，P < 0.01）。本研究将局部镇痛治疗软组织疼痛的治疗方法应用于身体的一个有问题的区域，并显示出治疗潜力。ClinicalTrials.gov 标识符：NCT05467631。
