Department of Gastroenterology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, China.
Department of Geriatric, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, China.
Sci Rep. 2024 Jul 26;14(1):17666. doi: 10.1038/s41598-024-68243-8.
Dietary intake of live microbes may benefit human health, but less is known about the role in insulin resistance. This study was developed with the goal of evaluating potential relationships between IR and dietary live microbes. The National Health and Nutrition Examination Survey (NHANES) dataset was leveraged to collect data from 6,333 subjects 18 + years of age. The Sanders system for the classification of dietary live microbe intake (containing Low (< 10 CFU/g), Medium (10-10 CFU/g), or High (> 10 CFU/g) levels of live microbes) was then used to separate these patients into three groups (low, medium, or high). Fasting blood glucose and insulin levels were used to approximate IR based on the homeostasis model of insulin resistance (HOMA-IR). Weighted linear regressions were used to assess the relationship between IR and live microbe intake. After fully adjusting for confounding factors, subjects in the groups exhibiting medium and high levels of live microbe intake exhibited HOMA-IR scores that were below those of subjects in the low group. The relationship between live microbe intake and HOMA-IR scores was also potentially impacted by ethnicity. In summary, a negative correlation was detected between dietary live microbe intake and HOMA-IR values.
饮食中摄入活菌可能有益于人类健康，但对于活菌在胰岛素抵抗中的作用知之甚少。本研究旨在评估 IR 与饮食中活菌之间的潜在关系。利用国家健康和营养调查（NHANES）数据集，从 6333 名 18 岁及以上的受试者中收集数据。然后使用桑德斯饮食活菌摄入量分类系统（包含低（<10 CFU/g）、中（10-10 CFU/g）或高（>10 CFU/g）水平的活菌）将这些患者分为三组（低、中或高）。根据胰岛素抵抗的稳态模型（HOMA-IR），空腹血糖和胰岛素水平用于估算 IR。使用加权线性回归评估 IR 与活菌摄入量之间的关系。在充分调整混杂因素后，摄入中、高水平活菌的组的 HOMA-IR 评分低于摄入低水平活菌的组。活菌摄入量与 HOMA-IR 评分之间的关系也可能受到种族的影响。总之，饮食中活菌的摄入与 HOMA-IR 值之间存在负相关。
