支链氨基酸与高血压风险；一项基于波斯人群队列的研究。
Branched-chain amino acids and the risk of hypertension; a persian cohort-based study.
作者信息
Salimi Zahra, Aminnezhad Kavkani Bahareh, Allahyari Pooneh, Askarpour Seyed Ali, Mahmoudi Zahra, Torkaman Mahdie, Hoseini Mohadeseh Sadat Mousavi, Mousavi Zahra, Tajadod Shirin, Valisoltani Neda, Khoshdooz Sara, Doaei Saeid, Kooshki Akram, Gholamalizadeh Maryam
机构信息
Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutrition. Science and Research Branch, Islamic Azad University, Tehran, Iran.
出版信息
BMC Cardiovasc Disord. 2024 Jul 31;24(1):397. doi: 10.1186/s12872-024-04045-0.
BACKGROUND
The association of hypertension (HTN) and different types of dietary amino acids is not yet clear. The aim of the present study was to investigate the association of branch chain amino acids (BCAAs) and the prevention of HTN.
METHODS
This cross-sectional study was conducted on 4184 people aged 35 to 70 using data from the Sabzevar Persian cohort study in Sabzevar, Iran. Data on dietary intake of BCAAs including leucine, isoleucine, and valine were obtained using a validated Food Frequency Questionnaire (FFQ). Multivariable logistic regression analysis assessed the link between HTN and BCAAs.
RESULTS
The results showed that participants with HTN had a higher total protein and BCAAs intake than participants with normal BP (P < 0.01). A marginally significant association was found between the risk of HTN with the total intake of BCAAs (OR = 1.018, CI95%: 1.001-1.035, P = 0.04), leucine (OR = 1.040, CI95%:1.002-1.080, P = 0.03), isoleucine (OR = 1.068, CI95%:1.001-1.140, P = 0.04), and valine (OR = 1.060, CI95%:1.003-1.121, P = 0.04). However, the association disappeared after adjusting the total protein and calorie intake.
CONCLUSIONS
The results indicated that the dietary intake of BCAAs may be associated with the risk of HTN. Future longitudinal research is warranted.
背景
高血压（HTN）与不同类型膳食氨基酸之间的关联尚不清楚。本研究旨在探讨支链氨基酸（BCAAs）与高血压预防之间的关联。
方法
本横断面研究使用来自伊朗萨卜泽瓦尔的萨卜泽瓦尔波斯队列研究的数据，对4184名35至70岁的人群进行了调查。使用经过验证的食物频率问卷（FFQ）获取包括亮氨酸、异亮氨酸和缬氨酸在内的支链氨基酸膳食摄入量数据。多变量逻辑回归分析评估了高血压与支链氨基酸之间的联系。
结果
结果显示，高血压患者的总蛋白质和支链氨基酸摄入量高于血压正常的参与者（P < 0.01）。在高血压风险与支链氨基酸总摄入量（OR = 1.018，CI95%：1.001 - 1.035，P = 0.04）、亮氨酸（OR = 1.040，CI95%：1.002 - 1.080，P = 0.03）、异亮氨酸（OR = 1.068，CI95%：1.001 - 1.140，P = 0.04）和缬氨酸（OR = 1.060，CI95%：1.003 - 1.121，P = 0.04）之间发现了边缘显著的关联。然而，在调整总蛋白质和卡路里摄入量后，这种关联消失了。
结论
结果表明，支链氨基酸的膳食摄入量可能与高血压风险有关。未来有必要进行纵向研究。
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