2型糖尿病与支链氨基酸（BCAA）之间的关联；一项病例对照研究。
Association between type 2 diabetes and branched chain amino acids (BCAA); a case-control study.
作者信息
Torki Saheb Abbas, Bahadori Effat, Aghakhaninejad Zohreh, Mohseni Golsa Khalatbari, Tajadod Shirin, Rajabi Harsini Asma, Azaryan Fatemeh, Saeedirad Zahra, Askarpour Seyed Ali, Mahmoudi Zahra, Khoshdooz Sara, Bahar Bojlul, Shafaei Hanieh, Mosavi Jarrahi Seyed Alireza, Doaei Saeid, Nazemi Samad, Gholamalizadeh Maryam
机构信息
Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
J Diabetes Metab Disord. 2023 Jul 22;22(2):1291-1297. doi: 10.1007/s40200-023-01247-9. eCollection 2023 Dec.
BACKGROUND
Several amino acids and their derivatives have been implicated in insulin resistance (IR) and Type 2 Diabetes Mellitus (T2DM). This research sought to establish a relationship between the dietary levels of branched-chain amino acids (BCAA) and the risk of T2DM.
METHODS
This case-control study was carried out on 4200 participants consisting of 589 people with T2DM and 3611 non-diabetic aged 35 to 70 years residents in Sabzevar, Iran. Data on the economic-social, employment status, medical history, lifestyle, and sleep habits were collected via interview. The food frequency questionnaire (FFQ) was used to check the nutritional status. Participants' dietary BCAA consumption was estimated using Nutritionist IV software.
RESULTS
A significant negative association between the incidence of T2DM and the dietary levels of BCAAs after adjustment for age and sex (OR = 0.972, CI 95%:0.648-0.996, P = 0.022). The negative association remained significant after additional adjustments for body mass index (BMI) and physical activity (OR = 0.967, CI 95%: 0.943-0.992, P = 0.010). Interestingly, a positive association was found between T2DM and total BCAAs (OR = 1.067, CI 95%: 1.017-1.119, P = 0.008), Isoleucine (OR = 1.248, CI 95%: 1.043-1.494, P = 0.016), Leucine (OR = 1.165, CI 95%: 1.046-1.299, P = 0.006) and Valine (OR = 1.274, CI 95%: 1.088-1.492, P = 0.003) after further adjustment for calorie intake.
CONCLUSIONS
Our results demonstrate branched-chain amino acids (BCAAs) including isoleucine, leucine, and valine are negatively associated with the incidence of type 2 diabetes (T2DM) after adjusting for age and sex, BMI, and physical activity. However, adjusting for calorie intake reversed the association between T2DM and BCAAs. These findings suggest that the association between BCAAs and T2DM may be influenced by calorie intake. Future longitudinal studies are warranted.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s40200-023-01247-9.
背景
几种氨基酸及其衍生物与胰岛素抵抗（IR）和2型糖尿病（T2DM）有关。本研究旨在确定支链氨基酸（BCAA）的饮食水平与T2DM风险之间的关系。
方法
本病例对照研究对4200名参与者进行，其中包括589名患有T2DM的人和3611名年龄在35至70岁之间的非糖尿病伊朗萨卜泽瓦尔居民。通过访谈收集经济社会、就业状况、病史、生活方式和睡眠习惯等数据。使用食物频率问卷（FFQ）来检查营养状况。参与者的饮食BCAA摄入量使用Nutritionist IV软件进行估算。
结果
在对年龄和性别进行调整后，T2DM发病率与BCAAs饮食水平之间存在显著负相关（OR = 0.972，95%CI：0.648 - 0.996，P = ）。在对体重指数（BMI）和身体活动进行进一步调整后，这种负相关仍然显著（OR = 0.967，95%CI：0.943 - 0.992，P = 0.010）。有趣的是，在对卡路里摄入量进行进一步调整后，发现T2DM与总BCAAs（OR = 1.067，95%CI：1.017 - 1.119，P = 0.008）、异亮氨酸（OR = 1.248，95%CI：1.043 - 1.494，P = 0.016）、亮氨酸（OR = 1.165，95%CI：1.046 - 1.299，P = 0.006）和缬氨酸（OR = 1.274，95%CI：1.088 - 1.492，P = 0.003）之间存在正相关。
结论
我们的结果表明，在对年龄、性别、BMI和身体活动进行调整后，包括异亮氨酸、亮氨酸和缬氨酸在内的支链氨基酸（BCAAs）与2型糖尿病（T2DM）的发病率呈负相关。然而，对卡路里摄入量进行调整后，T2DM与BCAAs之间的关联发生了逆转。这些发现表明，BCAAs与T2DM之间的关联可能受卡路里摄入量的影响。未来有必要进行纵向研究。
补充信息
在线版本包含可在10.1007/s40200 - 023 -
01247 - 9获取的补充材料。 （注：原文中“P = ”处数据缺失）
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