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0.05%阿托品滴眼液对近视进展和周边离焦的频率依赖性效应：一项前瞻性研究。

Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study.

作者信息

Yang Yuanfang, Xue Minsong, Hao Jiangdong, Lin Zhenghua, Xi Xiaoyun, Wu Haoran, Wen Longbo, Xu Qinglin, Luo Zhiwei, Ran Guangyao, Artal Pablo, Lan Weizhong, Li Xiaoning, Yang Zhikuan

机构信息

Aier School of Ophthalmology, Central South University, Changsha, 410015, China.

Aier Institute of Optometry and Vision Science, Changsha, 410015, China.

出版信息

Eye Vis (Lond). 2024 Aug 1;11(1):26. doi: 10.1186/s40662-024-00395-0.

DOI:10.1186/s40662-024-00395-0
PMID:39085950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11293060/
Abstract

BACKGROUND

Atropine, specifically 0.05% eyedrops, has proven effective in slowing myopia progression. This study aims to investigate peripheral refraction (PR) characteristics in myopic children treated with 0.05% atropine eyedrops at different frequencies.

METHODS

One hundred thirty-eight myopic children completed this one-year prospective study, randomly assigned to once daily (7/7), twice per week (2/7), or once per week (1/7) groups. Spherical equivalent (SE) and axial length (AL) were measured. PR was assessed using a custom-made Hartmann-Shack wavefront peripheral sensor, covering a visual field of horizontal 60° and vertical 36°. Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements.

RESULTS

After one year, SE increased more significantly in the 1/7 group compared to the 7/7 group (P < 0.001) and 2/7 group (P = 0.004); AL elongation was also greater in the 1/7 group compared to the 7/7 group (P < 0.001). In comparison with higher frequency groups, 1/7 group exhibited more myopic PR in the fovea and its vertical superior, inferior, and nasal retina; and less myopic RPR in the periphery retina after one-year (P < 0.05). Additionally, RPR in the 7/7 group demonstrated myopic shift across the entire retina, the 2/7 group in temporal and inferior retina, while the 1/7 group showed a hyperopic shift in the superior retina (P < 0.05). Moreover, myopic shift of RPR in the temporal retina is related to less myopia progression, notably in the 7/7 group (P < 0.05).

CONCLUSIONS

Atropine inhibits myopia progression in a frequency-dependent manner. The once-daily group showed the slowest myopia progression but exhibited more myopic shifts in RPR. Additionally, RPR in the temporal retina was related to myopia progression in all groups.

TRIAL REGISTRATION

Chinese Clinical Trial Registry, ChiCTR2100043506. Registered 21 February 2021, https://www.chictr.org.cn/showproj.html?proj=122214.

摘要

背景

阿托品，特别是0.05%的眼药水，已被证明对减缓近视进展有效。本研究旨在调查不同频率使用0.05%阿托品眼药水治疗的近视儿童的周边屈光（PR）特征。

方法

138名近视儿童完成了这项为期一年的前瞻性研究，随机分为每日一次（7/7）、每周两次（2/7）或每周一次（1/7）组。测量等效球镜度（SE）和眼轴长度（AL）。使用定制的哈特曼-夏克波前周边传感器评估PR，覆盖水平60°和垂直36°的视野。相对周边屈光（RPR）通过周边测量值减去中央测量值来计算。

结果

一年后，与7/7组（P < 0.001）和2/7组（P = 0.004）相比，1/7组的SE增加更为显著；与7/7组相比，1/7组的AL伸长也更大（P < 0.001）。与高频组相比，1/7组在黄斑及其垂直上方、下方和鼻侧视网膜表现出更多的近视性PR；一年后周边视网膜的近视性RPR更小（P < 0.05）。此外，7/7组的RPR在整个视网膜呈现近视性偏移，2/7组在颞侧和下方视网膜呈现近视性偏移，而1/7组在上方视网膜呈现远视性偏移（P < 0.05）。此外，颞侧视网膜RPR的近视性偏移与近视进展较慢有关，特别是在7/7组（P < 0.05）。

结论

阿托品以频率依赖的方式抑制近视进展。每日一次组的近视进展最慢，但RPR表现出更多的近视性偏移。此外，所有组中颞侧视网膜的RPR与近视进展有关。

试验注册

中国临床试验注册中心，ChiCTR2100043506。2021年2月21日注册，https://www.chictr.org.cn/showproj.html?proj=122214。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a102/11293060/0bbd154b66b2/40662_2024_395_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a102/11293060/32be8f933645/40662_2024_395_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a102/11293060/0bbd154b66b2/40662_2024_395_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a102/11293060/32be8f933645/40662_2024_395_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a102/11293060/3e4758fed8a1/40662_2024_395_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a102/11293060/e4eb1186342a/40662_2024_395_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a102/11293060/eb91d84f5980/40662_2024_395_Fig4_HTML.jpg
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