Roberts A H, Roberts F E, Hall R I, Thomas I H
J Hand Surg Br. 1985 Oct;10(3):370-4. doi: 10.1016/s0266-7681(85)80064-4.
A series of 418 patients with lacerations of the hands were allocated randomly to a control group or to a group where the injury was treated with povidone iodine before suture. The incidence of infected and imperfectly healed wounds was determined seven days later. As well as the effect of povidone iodine on infection, thirteen other factors were also analysed. The overall infection rate of 5.0% and the 38.5% imperfect healing rate were not significantly affected by povidone iodine treatment, although both were reduced. The figures of four other trials were combined with this trial and this showed a significant effect of povidone iodine treatment. There were no adverse reactions to povidone iodine. It is therefore recommended that hand lacerations should be treated with povidone iodine prior to suture. Other factors found to be significantly important in wound infection or imperfect healing were the condition of the dressing, the part of the hand injured and pain. Patients should be strongly advised to keep their dressing clean and dry.
418例手部裂伤患者被随机分为对照组和在缝合前用聚维酮碘处理伤口的组。七天后测定感染和愈合不佳伤口的发生率。除了聚维酮碘对感染的影响外，还分析了其他十三个因素。聚维酮碘治疗虽使总体感染率从5.0%和愈合不佳率从38.5%有所降低，但未产生显著影响。将该试验与其他四项试验的数据合并后显示，聚维酮碘治疗有显著效果。聚维酮碘无不良反应。因此建议手部裂伤在缝合前应用聚维酮碘处理。在伤口感染或愈合不佳方面发现其他显著重要的因素是敷料情况、手部受伤部位和疼痛。应强烈建议患者保持敷料清洁干燥。
