Roberts A H, Teddy P J
Br J Surg. 1977 Jun;64(6):394-6. doi: 10.1002/bjs.1800640605.
A series of 368 patients with hand lacerations which required suturing were randomly allocated to one of three treatment groups. The incidence of infected and of imperfectly healed wounds was noted 7 days after suturing. As well as the influence of antibiotics on healing, sixteen other factors which it was considered might affect healing were analysed. The overall infection rate was 9-8 per cent, and there was no significant difference between the three groups. The imperfect healing rate (which includes the infected cases) was 24-6 per cent. There was a lower rate (P less than 0-05) of imperfect healing in the Triplopen group (15 per cent) than in either the flucloxacillin group (29-5 per cent) or the group who received no antibiotics (29-0 per cent). Other factors associated with imperfect healing found to be significant at the 1 per cent level, were wound contamination, pain and the presence of a wet or changed dressing at the second examination.
368例需要缝合的手部裂伤患者被随机分配到三个治疗组之一。在缝合后7天记录感染伤口和愈合不佳伤口的发生率。除了抗生素对愈合的影响外，还分析了其他16个被认为可能影响愈合的因素。总体感染率为9.8%，三组之间无显著差异。愈合不佳率（包括感染病例）为24.6%。与氟氯西林组（29.5%）或未接受抗生素治疗组（29.0%）相比，曲普瑞林组愈合不佳率较低（P<0.05）（15%）。在1%的水平上发现与愈合不佳相关的其他因素包括伤口污染、疼痛以及第二次检查时敷料潮湿或更换。
