Miura M, Hiwatashi N
J Clin Lab Immunol. 1985 Oct;18(2):81-6.
Cytokine production from peripheral blood mononuclear cells, T-cell subsets and Ia positive monocytes in patients with inflammatory bowel disease were investigated. 26 patients with Crohn's disease (CD), 7 patients with ulcerative colitis (UC) and age and sex matched healthy donors (HD) as controls were studied. No differences were seen between UC and HD in any of the parameters examined. However, impairment of interleukin 2 and interferon production was noted in CD. They cannot be attributable to decreased number of T cells, because no significant differences were seen in the number of T cells including subsets. On the other hand, regarding interleukin 1 production, no differences were seen between HD and CD. These results suggest that some form of dysfunction exists at the T-cell level in the peripheral blood in CD.
对炎症性肠病患者外周血单个核细胞、T细胞亚群和Ia阳性单核细胞的细胞因子产生情况进行了研究。研究对象包括26例克罗恩病（CD）患者、7例溃疡性结肠炎（UC）患者以及年龄和性别相匹配的健康供者（HD）作为对照。在任何检测参数中，UC患者和HD之间均未发现差异。然而，CD患者中白细胞介素2和干扰素的产生受到损害。它们不能归因于T细胞数量的减少，因为包括亚群在内的T细胞数量没有显著差异。另一方面，关于白细胞介素1的产生，HD和CD之间未发现差异。这些结果表明，CD患者外周血中T细胞水平存在某种形式的功能障碍。
