Hashimoto K, Tanii H
Mutat Res. 1985 Dec;158(3):129-33. doi: 10.1016/0165-1218(85)90075-8.
Acrylamide and its 15 analogues have been tested for mutagenicity in 5 TA strains of Salmonella typhimurium. Acrylamide, N-tert-butylacrylamide, crotonamide, diacetone acrylamide, N,N-diethylacrylamide, N,N-dimethylacrylamide, N-hydroxymethylacrylamide, N-methylacrylamide, N-isobutoxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N,N'-methylene-bis-acrylamide and N-tert-octylacrylamide appeared not to be mutagenic in the standard Ames assay both with and without Aroclor 1254-induced S9, and in both the plate incubation and liquid preincubation procedures. Three epoxide analogues, i.e., glycidamide, N,N-diglycidyl acrylamide and glycidyl methacrylamide showed mutagenicity in one or two strains both with and without the S9.
已对丙烯酰胺及其15种类似物在5种鼠伤寒沙门氏菌TA菌株中进行了致突变性测试。在标准艾姆斯试验中，无论有无Aroclor 1254诱导的S9，以及在平板培养和液体预培养程序中，丙烯酰胺、N-叔丁基丙烯酰胺、巴豆酰胺、双丙酮丙烯酰胺、N,N-二乙基丙烯酰胺、N,N-二甲基丙烯酰胺、N-羟甲基丙烯酰胺、N-甲基丙烯酰胺、N-异丁氧基甲基丙烯酰胺、N-异丙基丙烯酰胺、甲基丙烯酰胺、N,N'-亚甲基双丙烯酰胺和N-叔辛基丙烯酰胺似乎均无致突变性。三种环氧化物类似物，即缩水甘油酰胺、N,N-二缩水甘油基丙烯酰胺和缩水甘油基甲基丙烯酰胺，无论有无S9，在一两种菌株中均表现出致突变性。
