Kirov State Medical University, Ministry of Health of the Russian Federation, Kirov, Russia.
Bull Exp Biol Med. 2024 Jun;177(2):181-184. doi: 10.1007/s10517-024-06152-6. Epub 2024 Aug 2.
We performed a comprehensive study of protein (total protein, medium-molecular-weight peptides, creatinine, and urea), purine (uric acid), and lipid (cholesterol, triglycerides) metabolism, activity of AST, ALT, and acid phosphatase in blood plasma of white male rats under conditions of restriction of motor activity up to 28 days. Patterns of changes in metabolic profile during hypokinesia were established: prevalence of catabolic processes and atherogenic shifts in the lipid spectrum with maximum manifestation on 14-21 days of the experiment.
我们对白鼠在限制运动条件下长达 28 天的血液中蛋白质（总蛋白、中分子肽、肌酐和尿素）、嘌呤（尿酸）和脂质（胆固醇、甘油三酯）代谢、AST、ALT 和酸性磷酸酶活性进行了全面研究。确定了在运动减少期间代谢特征的变化模式：分解代谢过程普遍存在，脂质谱呈现致动脉粥样硬化变化，在实验的第 14-21 天达到最大表现。
