Exercise Biochemistry Laboratory, Korea National Sport University, 1239, Yangjae-ro, Songpa-gu, Seoul, 05541, Korea.
Sport Science Institute, Korea National Sport University, 1239, Yangjae-ro, Songpa-gu, Seoul, 05541, Korea.
J Physiol Sci. 2024 Aug 2;74(1):39. doi: 10.1186/s12576-024-00930-7.
Many experts have extensively studied the potential of exercise as a treatment option for psychiatric conditions, including depression and autism spectrum disorder (ASD). Despite their core symptoms, these conditions exhibits comparable component traits, an anxiety. In this study, we explored the effect of exercise on behavioral abnormalities in psychiatric conditions, focusing on its intensity and emotional resilience. Shank3B knockout (KO) mice displaying self-injurious repetitive behavior and C57BL/6J mice, susceptible to stress as ASD and depression model, respectively, were subjected to moderate-intensity exercise (ME) for 2 weeks. ME mitigated the core symptoms (excessive grooming traits and behavioral despair) but did not exert a significant anxiolytic effect. Notably, exercise intensity has emerged as a critical determinant of its efficacy, as evidenced by a lower ventilation threshold and anxiolytic effect mediated by low-intensity exercise. The findings substantiate the notion that exercise is promising as a disease-modifying treatment, but intensity matters for emotional resilience.
许多专家广泛研究了运动作为治疗精神疾病的选择的潜力，包括抑郁症和自闭症谱系障碍（ASD）。尽管这些疾病具有核心症状，但它们表现出类似的组成特征，即焦虑。在这项研究中，我们探讨了运动对精神疾病中行为异常的影响，重点关注其强度和情绪弹性。表现出自伤性重复行为的 Shank3B 敲除（KO）小鼠和易受压力影响的 C57BL/6J 小鼠分别作为 ASD 和抑郁症模型，接受中等强度的运动（ME）治疗 2 周。ME 缓解了核心症状（过度梳理行为和行为绝望），但没有产生明显的抗焦虑作用。值得注意的是，运动强度是其疗效的关键决定因素，这一点可以通过较低的通气阈值和由低强度运动介导的抗焦虑作用得到证明。这些发现证实了运动作为一种疾病修饰治疗是有前途的，但强度对情绪弹性很重要。
