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肉桂醛对热应激诱导的Wistar大鼠睾丸损伤的效力评估。

Assessment of Cinnamaldehyde's Potency on Heat Stress-induced Testicular Impairments in Wistar Rats.

作者信息

Muthusamy Pazhanisankar, Wankhar Dapkupar, Paul Jeyakumari, Ravishankar Nivetha, Rajan Ravindran

机构信息

Department of Physiology, Dr. ALM PG IBMS, University of Madras, Chennai, Tamil Nadu, India.

Faculty of Paramedical Sciences, Assam Down Town University, Guwahati, Assam, India.

出版信息

J Hum Reprod Sci. 2024 Apr-Jun;17(2):102-111. doi: 10.4103/jhrs.jhrs_27_24. Epub 2024 May 28.

DOI:10.4103/jhrs.jhrs_27_24
PMID:39091438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11290720/
Abstract

BACKGROUND

Male sterility results from high testicular temperatures, which affect mammalian spermatogenesis. High testicular temperatures affect sperm motility, morphology and fertility according to their magnitude and duration.

AIM

The aim of the current study is to examine the effects of heat-induced oxidative stress and cinnamaldehyde on Wistar rat testicular structure and function.

SETTINGS AND DESIGN

The rats used in this experiment were Wistar albino rats.

MATERIALS AND METHODS

This research has six animals per group. Male Wistar albino rats of 2.5-3 months old and 275-300 g. (I) control, (II) heat stress (HS) in a closed chamber at 41°C for 14 days and (III) HS with cinnamaldehyde (CA) 50 mg/kg body weight for 14 days. (IV) CA alone. After the study, the animals were euthanised, and test samples were taken for sperm count, morphology, haematoxylin and eosin stain for normal cellular morphology, antioxidants and DNA integrity assessments.

STATISTICAL ANALYSIS USED

The data were analysed statistically using one- and two-way ANOVA tests for comparisons between groups.

RESULTS

The stress group had significantly lower sperm counts and poor sperm morphology. The stress group's antioxidant capacity is much lower than that of the control group. Animals under stress have fragmented DNA. Treatment with cinnamaldehyde increased overall antioxidant capacity and seminal parameters, and rats behaved most like controls.

CONCLUSION

CA restores malondialdehyde levels, total antioxidant capacity, sperm characteristics and mitigates testicular damage in rats exposed to experimental HS.

摘要

背景

雄性不育是由睾丸温度过高导致的，这会影响哺乳动物的精子发生。睾丸温度过高会根据其强度和持续时间影响精子活力、形态和生育能力。

目的

本研究的目的是检验热诱导的氧化应激和肉桂醛对Wistar大鼠睾丸结构和功能的影响。

设置与设计

本实验所用大鼠为Wistar白化大鼠。

材料与方法

本研究每组有6只动物。2.5 - 3个月大、体重275 - 300克的雄性Wistar白化大鼠。（I）对照组，（II）在封闭箱中于41°C热应激（HS）14天，（III）热应激同时给予50毫克/千克体重的肉桂醛（CA）14天。（IV）单独给予肉桂醛。研究结束后，对动物实施安乐死，并采集睾丸样本进行精子计数、形态学检查、苏木精和伊红染色以观察正常细胞形态、抗氧化剂及DNA完整性评估。

所用统计分析方法

采用单因素和双因素方差分析对数据进行统计学分析，以比较各组之间的差异。

结果

应激组的精子计数显著降低，精子形态不佳。应激组的抗氧化能力远低于对照组。应激状态下的动物存在DNA片段化。用肉桂醛治疗可提高总体抗氧化能力和精液参数，且大鼠的表现最接近对照组。

结论

肉桂醛可恢复丙二醛水平、总抗氧化能力、精子特征，并减轻暴露于实验性热应激的大鼠的睾丸损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9094/11290720/9873e20e1ef8/JHRS-17-102-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9094/11290720/6464f0c6d2b5/JHRS-17-102-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9094/11290720/5aa1a40b544c/JHRS-17-102-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9094/11290720/98c0484de643/JHRS-17-102-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9094/11290720/c47f76a9f485/JHRS-17-102-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9094/11290720/5aa1a40b544c/JHRS-17-102-g008.jpg
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本文引用的文献

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2
Exposure to tris(2-butoxyethyl) phosphate induces abnormal sperm morphology and testicular histopathology in male rats.接触磷酸三(2-丁氧基乙基)酯会导致雄性大鼠精子形态异常和睾丸组织病理学改变。
Ecotoxicol Environ Saf. 2022 Aug;241:113718. doi: 10.1016/j.ecoenv.2022.113718. Epub 2022 Jun 2.
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Effect of Co-exposure to Heat and Psychological Stressors on Sperm DNA and Semen Parameters.
热暴露与心理应激源共同作用对精子DNA和精液参数的影响。
Toxicol Rep. 2021 Nov 25;8:1948-1954. doi: 10.1016/j.toxrep.2021.11.015. eCollection 2021.
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Male infertility.男性不育症。
Lancet. 2021 Jan 23;397(10271):319-333. doi: 10.1016/S0140-6736(20)32667-2. Epub 2020 Dec 10.
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Transcriptomic and biochemical effects of pycnogenol in ameliorating heat stress-related oxidative alterations in rats.碧萝芷改善热应激相关氧化改变大鼠的转录组学和生化效应。
J Therm Biol. 2020 Oct;93:102683. doi: 10.1016/j.jtherbio.2020.102683. Epub 2020 Aug 21.
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