新冠病毒疫苗接种与月经紊乱：来自巴基斯坦的一项前瞻性研究。
COVID-19 vaccination and menstrual disturbances: A prospective study from Pakistan.
作者信息
Parveen Nuzhat
出版信息
Pak J Med Sci. 2024 Aug;40(7):1345-1348. doi: 10.12669/pjms.40.7.8709.
OBJECTIVE
To evaluate whether or not immunization against COVID-19 is associated with changes in the duration and frequency of the menstrual cycle.
METHODS
This prospective analysis included the menstrual cycle data of 154 females after COVID-19 vaccination from August 2021 to March 2022. This study included Pakistani females aged 18 to 45 years and who had taken at-least one dose of COVID-19 vaccination. After two months of COVID vaccine the participants were interviewed again about the timing and duration of their menstrual cycle. The increase in menstrual length for >eight days was labelled as increased menstrual cycle duration.
RESULTS
Mean age of participants was 33.53±8.52 years. Among 154, 113 (73.4%) were married. Among 154 females, menstrual abnormality was reported by 59 (38.3%) females, increase in cycle duration was reported by 25 (16.2%) patients and decrease by 22 (14.3%), increase in number of bleeding days by 20 (13%) females and decrease by 15 (9.7%), increase in pain intensity was reported by 19 (12.3%) females and decrease by 17 (11.0%), increased intensity of blood flow was reported by 20 (13.0%) patients and decreased intensity by 19 (12.3%) females.
CONCLUSION
COVID-19 vaccination is not associated with menstrual abnormalities in a significant number of females.
目的
评估接种新型冠状病毒肺炎（COVID-19）疫苗是否与月经周期的时长和频率变化有关。
方法
这项前瞻性分析纳入了2021年8月至2022年3月期间154名女性接种COVID-19疫苗后的月经周期数据。本研究纳入了年龄在18至45岁之间且至少接种过一剂COVID-19疫苗的巴基斯坦女性。在接种COVID疫苗两个月后，再次询问参与者月经周期的时间和时长。月经长度增加超过八天被标记为月经周期时长增加。
结果
参与者的平均年龄为33.53±8.52岁。在154名参与者中，113名（73.4%）已婚。在154名女性中，59名（38.3%）女性报告有月经异常，25名（16.2%）患者报告周期时长增加，22名（14.3%）报告周期时长减少，20名（13%）女性报告出血天数增加，15名（9.7%）报告出血天数减少，19名（12.3%）女性报告疼痛强度增加，17名（11.0%）报告疼痛强度减少，20名（13.0%）患者报告血流强度增加，19名（12.3%）女性报告血流强度减少。
结论
大量女性接种COVID-19疫苗与月经异常无关。
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