These authors contributed equally to this work and share first authorship.
National Reference Center for Whooping Cough and other Bordetella infections, Institut Pasteur, Paris, France.
Euro Surveill. 2024 Aug;29(31). doi: 10.2807/1560-7917.ES.2024.29.31.2400459.
As other European countries, France is experiencing a resurgence of pertussis in 2024. Between 1 January and 31 May 2024, 5,616 (24.9%) positive qPCR tests were identified, following a 3-year period of almost null incidence. Of 67 cultured and whole genome sequenced isolates, 66 produced pertactin and 56 produced FIM2, in contrast to pre-COVID-19 years. One isolate of genotype Bp-AgST4 was resistant to macrolides. Pertussis resurgence may favour isolates that produce FIM2 and pertactin.
与其他欧洲国家一样，法国在 2024 年也经历了百日咳的死灰复燃。在 2024 年 1 月 1 日至 5 月 31 日期间，在经历了近 3 年几乎零发病率后，有 5616 例（24.9%）经 qPCR 检测呈阳性。在 67 株培养和全基因组测序的分离株中，66 株产生 pertactin，56 株产生 FIM2，与 COVID-19 之前的年份形成对比。一株 Bp-AgST4 基因型的分离株对大环内酯类药物具有耐药性。百日咳的死灰复燃可能有利于产生 FIM2 和 pertactin 的分离株。
