Department of Laboratory, Taian Maternity And Child Health Hospital, No.386 Longtan Road, Gaoxin District, Tai'an, 271000, People's Republic of China.
Department of Blood Transfusion, Taian Maternity And Child Health Hospital, Tai'an, 271000, People's Republic of China.
BMC Womens Health. 2023 Sep 14;23(1):487. doi: 10.1186/s12905-023-02631-6.
The objective of the present study was to investigate whether associations exist between inflammatory biomarkers and all-cause mortality and cardiovascular disease (CVD) mortality in women with postmenopausal osteoporosis (PMOP) or osteopenia.
In this retrospective cohort study, data were obtained from the National Health and Nutrition Examination Survey database from the years 2007 to 2010, 2013 to 2014, and 2017 to 2018. The inflammatory biomarkers including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), neutrophil × platelet/lymphocyte (SII), neutrophil × monocyte/lymphocyte (SIRI), and neutrophil × monocyte × platelet/lymphocyte ratio (AISI) were calculated.
A total of 2,834 women were included, with a median survival of 113.51 (3.15) months. During follow-up, 602 women died of all-cause mortality and 185 women died of CVD. NLR, MLR, SIRI, and AISI were significantly associated with all-cause mortality in postmenopausal women with osteoporosis or osteopenia. NLR, MLR, SIRI, and AISI were related to CVD mortality in postmenopausal women with osteoporosis or osteopenia (All P < 0.05). Based on the results of the subgroup analysis, AISI, SIRI, and MLR were associated with all-cause mortality and CVD mortality in postmenopausal women with PMOP or osteopenia who had a history of CVD and diabetes. AISI, SII, MLR, and NLR were associated with all-cause mortality and CVD mortality in PMOP or osteopenia women with a body mass index (BMI) > 25 kg/m. PLR was associated with all-cause mortality in PMOP or osteopenia women aged ≥ 65 years.
Inflammatory biomarkers were correlated with mortality risk in the PMOP or osteopenia population. This finding may be helpful for the prognosis management of PMOP or osteopenia in postmenopausal women.
本研究旨在探讨绝经后骨质疏松症（PMOP）或骨量减少症患者的炎症生物标志物与全因死亡率和心血管疾病（CVD）死亡率之间是否存在关联。
本回顾性队列研究的数据来自 2007 年至 2010 年、2013 年至 2014 年和 2017 年至 2018 年的全国健康与营养调查数据库。炎症生物标志物包括中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、单核细胞/淋巴细胞比值（MLR）、中性粒细胞×血小板/淋巴细胞（SII）、中性粒细胞×单核细胞/淋巴细胞（SIRI）和中性粒细胞×单核细胞×血小板/淋巴细胞比值（AISI）。
共纳入 2834 名女性，中位生存时间为 113.51（3.15）个月。随访期间，602 名女性死于全因死亡率，185 名女性死于 CVD。NLR、MLR、SIRI 和 AISI 与 PMOP 或骨量减少症女性的全因死亡率显著相关。NLR、MLR、SIRI 和 AISI 与 PMOP 或骨量减少症女性的 CVD 死亡率相关（均 P<0.05）。根据亚组分析结果，AISI、SIRI 和 MLR 与患有 CVD 和糖尿病的 PMOP 或骨量减少症绝经后妇女的全因死亡率和 CVD 死亡率相关。AISI、SII、MLR 和 NLR 与 BMI>25kg/m2 的 PMOP 或骨量减少症女性的全因死亡率和 CVD 死亡率相关。PLR 与年龄≥65 岁的 PMOP 或骨量减少症女性的全因死亡率相关。
炎症生物标志物与 PMOP 或骨量减少症人群的死亡风险相关。这一发现可能有助于绝经后 PMOP 或骨量减少症患者的预后管理。
