Xia Qingyue, Wang Zhaopeng, Tang Yingdan, Luan Xingbao, Deng Tianxurun, Fan Lipan, Wu Hongjin, Li Yuan, Cui Xiaomei, Zhao Yang, Luo Dan
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
J Cosmet Dermatol. 2024 Dec;23(12):4129-4139. doi: 10.1111/jocd.16499. Epub 2024 Aug 2.
The severity and treatment response of acne, melasma, and rosacea may be influenced by various currently unclear internal and external factors. This study aimed to provide evidence to the influencing factors for the mentioned conditions through a real-world case-control study.
An online survey consisting of 60 questions was implemented, collecting information on demographics, socioeconomics, genetic factors, lifestyle habits, environmental exposures, and skin care behaviors. Then we constructed univariate and multivariate logistic regressions. Furthermore, we analyzed the dose-response relationship between exposure and outcome.
A total of 399 individuals, including 94 acne patients, 107 melasma patients, and 91 rosacea patients were included. Acne and melasma were positively correlated with screen time (acne: odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.25-4.02; melasma: OR: 1.59, 95% CI: 1.09-2.31), while exercise exerted a protective effect on both acne (OR: 0.31, 95% CI: 0.13-0.77) and melasma (OR: 0.42, 95% CI: 0.22-0.80) in a dose-response relationship. In addition, males were associated with an elevated risk of acne (OR: 6.62, 95% CI: 1.01-43.26). Aging (OR: 1.15, 95% CI: 1.07-1.24) and irregular bowel movements (OR: 2.99, 95% CI: 1.11-8.08) were independent risk factors for melasma. Rosacea was positively associated with BMI (OR: 1.17, 95% CI: 1.01-1.35).
In our study, we highlighted exercise as an independent protective factor for both acne and melasma in a dose-response trend. Inversely, extended use of electronic equipment was independently associated with higher risks of acne and melasma. Rosacea, however, was more likely to be related with BMI.
痤疮、黄褐斑和玫瑰痤疮的严重程度及治疗反应可能受到目前尚不清楚的多种内外因素影响。本研究旨在通过一项真实世界病例对照研究，为上述病症的影响因素提供证据。
开展了一项包含60个问题的在线调查，收集人口统计学、社会经济学、遗传因素、生活习惯、环境暴露及皮肤护理行为等方面的信息。然后构建单因素和多因素逻辑回归模型。此外，还分析了暴露与结局之间的剂量反应关系。
共纳入399名个体，其中包括94名痤疮患者、107名黄褐斑患者和91名玫瑰痤疮患者。痤疮和黄褐斑与屏幕使用时间呈正相关（痤疮：比值比[OR]：2.24，95%置信区间[CI]：1.25 - 4.02；黄褐斑：OR：1.59，95% CI：1.09 - 2.31），而运动对痤疮（OR：0.31，95% CI：0.13 - 0.77）和黄褐斑（OR：0.42，95% CI：0.22 - 0.80）均具有剂量反应关系的保护作用。此外，男性患痤疮的风险升高（OR：6.62，95% CI：1.01 - 43.26）。年龄增长（OR：1.15，95% CI：1.07 - 1.24）和排便不规律（OR：2.99，95% CI：1.11 - 8.08）是黄褐斑的独立危险因素。玫瑰痤疮与体重指数呈正相关（OR：1.17，95% CI：1.01 - 1.35）。
在我们的研究中，我们强调运动在剂量反应趋势上是痤疮和黄褐斑的独立保护因素。相反，电子设备的长时间使用与痤疮和黄褐斑的较高风险独立相关。然而，玫瑰痤疮更可能与体重指数有关。
