免疫疗法和肝癌研究趋势及 100 篇高被引文章：文献计量分析。
Immunotherapy and liver cancer research trends and the 100 most cited articles: A bibliometric analysis.
机构信息
Department of Hepatobiliary and Pancreatic Surgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Key Laboratory, Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China.
出版信息
Technol Health Care. 2024;32(6):5141-5155. doi: 10.3233/THC-241111.
BACKGROUND
Bibliometric analysis of liver cancer research, particularly in immunotherapy, reveals crucial insights. The US leads in liver cancer mortality but ranks fifth globally.
OBJECTIVE
Scopus database analysis identified 2,349 papers, with the top 100 ranging from 127 to 4,959 citations. Notably, "Microenvironmental Regulation of Tumours Progression and Metastasis" in the Journal of Nature Medicine garnered the highest citations.
METHODS
Journals like the Journal of Hepatology, Hepatology, and Nature Reports Clinical Oncology contributed significantly. Understanding molecular mechanisms and prognostic indicators is paramount for advancing combination therapies.
RESULTS
For better patient outcomes, research trends in liver cancer immunotherapy point to improved treatment protocols, knowledge of the tumor microenvironment, combining therapies, predicting disease course, international cooperation, sophisticated surgical techniques, early detection, oncolytic virotherapy, and patient-centered care.
CONCLUSIONS
This research underscores immunotherapy's pivotal role and encourages further exploration, offering valuable insights into liver cancer treatment trends.
背景
对肝癌研究，特别是免疫疗法的文献计量分析揭示了关键见解。美国在肝癌死亡率方面处于领先地位，但在全球排名第五。
目的
Scopus 数据库分析确定了 2349 篇论文，其中排名前 100 的论文被引次数在 127 到 4959 次之间。值得注意的是，《自然医学杂志》上的“肿瘤进展和转移的微环境调控”一文获得了最高引用。
方法
《肝脏病学杂志》、《肝脏病学》和《自然评论临床肿瘤学》等期刊做出了重要贡献。了解分子机制和预后指标对于推进联合治疗至关重要。
结果
为了改善患者的预后，肝癌免疫疗法的研究趋势指向改进治疗方案、了解肿瘤微环境、联合治疗、预测疾病进程、国际合作、复杂的手术技术、早期检测、溶瘤病毒疗法和以患者为中心的护理。
结论
这项研究强调了免疫疗法的关键作用，并鼓励进一步探索，为肝癌治疗趋势提供了有价值的见解。
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