Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2406621. doi: 10.1080/21645515.2024.2406621. Epub 2024 Oct 14.
Oncolytic virotherapy in combination with immunotherapy has demonstrated significant survival benefits in some types of cancer. Here, we summarized the development, research hotpots and potential trends of the combination therapy using visual bibliometric analysis. A total of 712 articles were retrieved on June 21, 2023. The USA was the top contributors of any country (325, 45.65%), and the Rluk Research Libraries UK ranked first (43, 6.03%) of any institutions. The Journal for ImmunoTherapy of Cancer was with the largest publications (60, 8.43%). 'Tumor microenvironment' and 'delivery' were citation keywords with the strongest ongoing bursts. Research fronts in the future may focus on the methods of virus delivery and tumor microenvironment modulation. Futhermore, the most extensively studied cancer were melanoma, glioma and hepatocellular carcinoma.
溶瘤病毒治疗联合免疫治疗在某些类型的癌症中显示出显著的生存获益。在这里，我们通过可视化文献计量分析总结了该联合治疗的发展、研究热点和潜在趋势。于 2023 年 6 月 21 日检索到了 712 篇文章。美国是任何国家（325，45.65%）中发文量最多的国家，而 Rluk 研究图书馆英国（43，6.03%）是任何机构中发文量最多的机构。《癌症免疫治疗杂志》的发文量最大（60，8.43%）。“肿瘤微环境”和“递送”是引文关键词中具有最强持续爆发的两个关键词。未来的研究前沿可能集中在病毒递送和肿瘤微环境调节的方法上。此外，研究最多的癌症是黑色素瘤、神经胶质瘤和肝细胞癌。
