Department of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, 310029, China.
Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310027, China.
Nat Commun. 2024 Aug 2;15(1):6528. doi: 10.1038/s41467-024-50375-0.
Cutting edge advances in electrical visual cortical prosthetics have evoked perception of shapes, motion, and letters in the blind. Here, we present an alternative optical approach using pulsed infrared neural stimulation. To interface with dense arrays of cortical columns with submillimeter spatial precision, both linear array and 100-fiber bundle array optical fiber interfaces were devised. We deliver infrared stimulation through these arrays in anesthetized cat visual cortex and monitor effects by optical imaging in contralateral visual cortex. Infrared neural stimulation modulation of response to ongoing visual oriented gratings produce enhanced responses in orientation-matched domains and suppressed responses in non-matched domains, consistent with a known higher order integration mediated by callosal inputs. Controls include dynamically applied speeds, directions and patterns of multipoint stimulation. This provides groundwork for a distinct type of prosthetic targeted to maps of visual cortical columns.
在电视觉皮质假体方面的前沿进展已经使盲人能够感知形状、运动和字母。在这里，我们提出了一种使用脉冲红外神经刺激的替代光学方法。为了与具有亚毫米空间精度的密集皮质柱阵列接口，设计了线性阵列和 100 光纤束阵列光纤接口。我们通过这些阵列在麻醉猫的视觉皮层中传递红外刺激，并通过在对侧视觉皮层中的光学成像来监测效果。红外神经刺激调制对正在进行的视觉定向光栅的反应会在匹配方向的区域中产生增强的反应，而在不匹配的区域中抑制反应，这与通过胼胝体输入介导的已知的高级整合一致。对照包括动态应用的速度、方向和多点刺激模式。这为一种针对视觉皮质柱图谱的独特类型的假体奠定了基础。
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