重症监护病房患者的医院获得性肺炎
Nosocomial pneumonia in patients in intensive care units.
作者信息
Podnos S D, Toews G B, Pierce A K
出版信息
West J Med. 1985 Nov;143(5):622-7.
Abstract
Nosocomial pneumonia is a major cause of mortality among patients in intensive care units, despite recent advances in antimicrobial therapy. Aerobic Gram-negative bacilli remain the pathogens responsible for most of these pneumonias. These organisms colonize the oropharynx of severely ill patients, and their subsequent aspiration results in lower respiratory tract infection. Recent investigation into the pathogenesis of oropharyngeal bacterial colonization has shown the central importance of bacterial adherence mechanisms.
摘要
尽管抗菌治疗最近取得了进展，但医院获得性肺炎仍是重症监护病房患者死亡的主要原因。需氧革兰氏阴性杆菌仍然是导致这些肺炎的主要病原体。这些微生物在重症患者的口咽部定植，随后被误吸导致下呼吸道感染。最近对口咽部细菌定植发病机制的研究表明，细菌黏附机制至关重要。
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