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发展中国家儿童行完全修复法洛四联症时采用经食管超声心动图指导的暖血心脏不停跳手术的早期结果

Early outcomes of experience warm surgery in children undergoing complete repair of tetralogy of Fallot in developing countries.

机构信息

University Children's Hospital, Damascus University, Damascus, Syrian Arab Republic.

出版信息

BMC Pediatr. 2024 Aug 3;24(1):499. doi: 10.1186/s12887-024-04976-9.

Abstract

OBJECTIVES

While significant evidence supports the benefits of normothermic cardiopulmonary bypass (NCPB) over hypothermic techniques, many institutions in developing countries, including ours, continue to employ hypothermic methods. This study aimed to assess the early postoperative outcomes of normothermic cardiopulmonary bypass (NCPB) for complete surgical repair via the Tetralogy of Fallot (TOF) within our national context.

METHODS

We conducted this study in the Pediatric Cardiac Intensive Care Unit (PCICU) at the University Children's Hospital. One hundred patients who underwent complete TOF repair were enrolled and categorized into two groups: the normothermic group (n = 50, temperature 35-37 °C) and the moderate hypothermic group (n = 50, temperature 28-32 °C). We evaluated mortality, morbidity, and postoperative complications in the PCICU as outcome measures.

RESULTS

The demographic characteristics were similar between the two groups. However, the cardiopulmonary bypass (CPB) time and aortic cross-clamp (ACC) time were notably longer in the hypothermic group. The study recorded seven deaths, yielding an overall mortality rate of 7%. No significant differences were observed between the two groups concerning mortality, morbidity, or postoperative complications in the PCICU.

CONCLUSIONS

Our findings suggest that normothermic procedures, while not demonstrably effective, are safe for pediatric cardiac surgery. Further research is warranted to substantiate and endorse the adoption of this technique.

摘要

目的

尽管有大量证据支持常温体外循环(NCPB)优于低温技术,但包括我们医院在内的许多发展中国家的机构仍在使用低温方法。本研究旨在评估我们国家常温体外循环(NCPB)在完全通过法洛四联症(TOF)进行心脏手术修复中的早期术后结果。

方法

我们在大学儿童医院的儿科心脏重症监护病房(PCICU)进行了这项研究。共纳入了 100 名接受完全 TOF 修复的患者,并将他们分为两组:常温组(n=50,温度 35-37°C)和中度低温组(n=50,温度 28-32°C)。我们评估了 PCICU 中的死亡率、发病率和术后并发症作为结局指标。

结果

两组的人口统计学特征相似。然而,低温组的体外循环(CPB)时间和主动脉阻断(ACC)时间明显更长。该研究记录了 7 例死亡,总死亡率为 7%。两组在 PCICU 中的死亡率、发病率或术后并发症方面无显著差异。

结论

我们的发现表明,常温手术虽然没有明显的效果,但对儿科心脏手术是安全的。需要进一步的研究来证实和支持采用这种技术。

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