Chermon Danyel, Birk Ruth
Nutrition Department, Health Sciences Faculty, Ariel University, Ariel, Israel.
J Obes Metab Syndr. 2024 Sep 30;33(3):251-260. doi: 10.7570/jomes23066. Epub 2024 Aug 5.
Src homology 2 B adaptor protein 1 () gene and variants have been found to be associated with common obesity. We aimed to investigate the association between the common missense variant rs7498665 and common obesity risk as well as interactions with lifestyle variables in an Israeli population.
An adult cohort (n=3,070; ≥18 years) with the rs7498665 variant and lifestyle, behavior (online questionnaire), and blood glucose data was analyzed. Associations between this variant, obesity risk (body mass index [BMI] ≥25 and ≥30 kg/m), and interactions with behavioral and lifestyle factors (stress levels, eating habits score [EHS], physical activity [PA], and wine consumption) were investigated. Association and gene-environment interactions were analyzed using binary logistic regressions with interaction.
rs7498665 carriers were significantly (<0.05) more likely to be overweight (BMI ≥25 kg/m) or obese (BMI ≥30 kg/m) in recessive (odds ratio [OR], 1.90 and 1.36, respectively), additive (OR, 1.24 and 1.14, respectively), and codominant (OR, 2.00 and 1.41, respectively) genetic models. rs7498665 interacted with lifestyle and behavioral factors as well as glucose levels. PA and moderate wine consumption (1 to 3 drinks/week) reduced obesity risk (OR, 0.35 and 0.71, respectively). Conversely, carriers of two risk alleles who reported high stress levels, had ≥median EHS, and who had a fasting glucose level ≥90 mg/dL had a significantly increased obesity risk (OR, 3.63 and 5.82, respectively).
Carrying rs7498665 significantly elevates the risk of obesity. Actionable lifestyle and behavioral factors significantly modulate the rs7498665 genetic predisposition to obesity; PA and moderate wine consumption attenuate the risk, while high stress, EHS, and fasting glucose level increase the obesity risk.
已发现Src同源2 B衔接蛋白1（）基因及其变体与普通肥胖有关。我们旨在研究常见错义变体rs7498665与普通肥胖风险之间的关联，以及在以色列人群中与生活方式变量的相互作用。
对一个成年队列（n = 3070；年龄≥18岁）进行分析，该队列具有rs7498665变体以及生活方式、行为（在线问卷）和血糖数据。研究了该变体与肥胖风险（体重指数[BMI]≥25和≥30 kg/m²）之间的关联，以及与行为和生活方式因素（压力水平、饮食习惯评分[EHS]、身体活动[PA]和饮酒量）的相互作用。使用带有相互作用的二元逻辑回归分析关联和基因-环境相互作用。
在隐性（优势比[OR]分别为1.90和1.36）、加性（OR分别为1.24和1.14）和共显性（OR分别为2.00和1.41）遗传模型中，rs7498665携带者超重（BMI≥25 kg/m²）或肥胖（BMI≥30 kg/m²）的可能性显著更高（P<0.05）。rs7498665与生活方式和行为因素以及血糖水平存在相互作用。身体活动和适度饮酒（每周1至3杯）可降低肥胖风险（OR分别为0.35和0.71）。相反，报告高压力水平、EHS≥中位数且空腹血糖水平≥90 mg/dL的两个风险等位基因携带者肥胖风险显著增加（OR分别为3.63和5.82）。
携带rs7498665会显著增加肥胖风险。可采取行动的生活方式和行为因素可显著调节rs7498665对肥胖的遗传易感性；身体活动和适度饮酒可降低风险，而高压力、EHS和空腹血糖水平会增加肥胖风险。
