Hacettepe University Medical School, Department of Physical and Rehabilitation Medicine, Turkey.
Hacettepe University Medical School, Department of Physical and Rehabilitation Medicine, Turkey.
J Clin Densitom. 2024 Oct-Dec;27(4):101509. doi: 10.1016/j.jocd.2024.101509. Epub 2024 Jul 16.
Although different dual-energy X-ray absorptiometry (DXA) scanners provide different bone mineral density (BMD) values, there is not a gold standard DXA scanner. T-score is used to facilitate the interpretation of BMD, and osteoporosis (OP) is diagnosed based on T-scores. In this retrospective study, we aimed to evaluate the BMD and T-score differences between Lunar Prodigy and Hologic Horizon DXA scanners.
Data were collected for patients with previous BMD measurement on Lunar Prodigy and Hologic Horizon DXA scanners within one year in the same medical center.
In a total of 55 patients, BMD values of femoral neck/total, and lumbar vertebrae were all lower at Hologic than Lunar (all p < 0.01). The mean T-score difference at the lumbar spine was 0.74 ± 0.42 (p < 0.001). Of the 49 patients diagnosed as OP (T-score ≤-2.5) with the Hologic, the diagnoses were changed for 25 individuals (51.0 %) with Lunar (p < 0.001). Herewith, although the diagnoses of OP did not change by the repeat technique in other 24 patients (49 %), 13 of them (26.5 %) were categorized as having "high fracture risk" instead of "very high fracture risk" group (i.e., T-score <-3.0). We observed moderate-to-good reliabilities (with an intraclass correlation coefficient [ICC] of 0.633-0.878 and 0.733-0.842 for BMD and T-scores, respectively) between measurements with the Lunar and Hologic scanners. Except for one measurement in L3, L4, L1-4 vertebrae, the Bland-Altman plot did not reveal any consistent bias between the measurements of the Lunar and Hologic scanners.
The consistency between different DXA scanners (especially for Hologic vs. Lunar) is important for proper management, especially in patients with low T-scores and OP.
尽管不同的双能 X 射线吸收仪（DXA）扫描仪提供了不同的骨密度（BMD）值，但并没有一个黄金标准的 DXA 扫描仪。T 评分用于促进 BMD 的解读，骨质疏松症（OP）则根据 T 评分来诊断。在这项回顾性研究中，我们旨在评估 Lunar Prodigy 和 Hologic Horizon DXA 扫描仪之间的 BMD 和 T 评分差异。
我们收集了同一医疗中心一年内在 Lunar Prodigy 和 Hologic Horizon DXA 扫描仪上进行过先前 BMD 测量的患者的数据。
在总共 55 名患者中，股骨颈/总骨和腰椎的 BMD 值在 Hologic 扫描仪上均低于 Lunar 扫描仪（均 p<0.01）。腰椎 T 评分差值的平均值为 0.74±0.42（p<0.001）。在 49 名被诊断为 OP（T 评分≤-2.5）的患者中，25 名患者（51.0%）的诊断结果因 Lunar 扫描仪而发生改变（p<0.001）。虽然在其他 24 名患者（49%）中，重复技术并未改变 OP 的诊断，但其中 13 名患者（26.5%）被归类为“高骨折风险”而不是“极高骨折风险”组（即 T 评分<-3.0）。我们观察到 Lunar 和 Hologic 扫描仪之间的测量结果具有中等至良好的可靠性（BMD 和 T 评分的组内相关系数[ICC]分别为 0.633-0.878 和 0.733-0.842）。除了 L3、L4、L1-4 椎体的一个测量值外，Bland-Altman 图未显示 Lunar 和 Hologic 扫描仪之间的任何一致偏差。
不同 DXA 扫描仪之间的一致性（特别是 Hologic 与 Lunar 之间）对于适当的管理很重要，尤其是在 T 评分低和 OP 患者中。
