Department of Biology, Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Tissue Cell. 2024 Oct;90:102509. doi: 10.1016/j.tice.2024.102509. Epub 2024 Jul 31.
Heat stress from varicocele can heighten oxidative stress in the testes, impacting sperm function and male fertility. Antioxidant therapy is explored as a remedy for varicocele, while dietary factors like processed foods, sugar, and saturated fats correlate with male infertility. Advanced glycation end products (AGEs), generated through glycation processes, can provoke oxidative stress, inflammation, and adverse health consequences. Alpha-lipoic acid (ALA), a versatile antioxidant, may alleviate oxidative stress and counteract the impact of AGEs, potentially by enhancing glucose reabsorption. Alagebrium chloride (ALT711), an anti-AGE compound, exhibits promise in cardiovascular disease by disrupting AGE cross-links. This study investigates the effects of ALA and ALT-711 on testicular function in varicocele and AGEs animal models. Both AGE and varicocele were found to alter the natural trends, leading to abnormal patterns in sperm parameters, testicular functional tests, as well as the expression of CML, RAGE, and TNF-α proteins. However, the administration of ALA or ALT711 helped mitigate these effects. While ALA demonstrated a slightly greater overall benefit compared to ALT, the difference was not statistically significant.
精索静脉曲张引起的热应激会加剧睾丸中的氧化应激，影响精子功能和男性生育能力。抗氧化治疗被探索作为精索静脉曲张的一种治疗方法，而饮食因素如加工食品、糖和饱和脂肪与男性不育有关。通过糖化过程产生的晚期糖基化终产物 (AGEs) 会引发氧化应激、炎症和不良健康后果。α-硫辛酸 (ALA) 作为一种多功能抗氧化剂，可能通过增强葡萄糖重吸收来缓解氧化应激并抵消 AGEs 的影响。AGE 交联的抗 AGE 化合物 ALagebrium 氯化物 (ALT711) 在心血管疾病方面显示出前景。本研究调查了 ALA 和 ALT-711 对精索静脉曲张和 AGEs 动物模型中睾丸功能的影响。AGE 和精索静脉曲张都改变了自然趋势，导致精子参数、睾丸功能测试以及 CML、RAGE 和 TNF-α 蛋白的表达出现异常模式。然而，ALA 或 ALT711 的给药有助于减轻这些影响。虽然 ALA 与 ALT 相比总体上具有更大的益处，但差异没有统计学意义。
