Lackner F, Graninger W, Khosropour R
Anaesthesist. 1985 Sep;34(9):470-3.
In 18 adult patients, in a randomized way, 15 ml/kg of blood were replaced either by gelatin 5.5 pc or serum protein solution. 0,5, 4 and 24 h later there was only a significant difference between the two groups in total protein and serum albumin. The low molecular weight infection related proteins alpha-1-antitrypsin, immunoglobulin G and antithrombin III, as well as the high molecular weight proteins immunoglobulin M, plasma fibronectin and alpha-2-macroglobulin were at no time significantly different between the two groups. It is concluded that gelatin as a plasma substitute does not impair the opsonising effect of plasma fibronectin upon the reticuloendothelial system.
在18例成年患者中，以随机方式用5.5%明胶或血清蛋白溶液替代15ml/kg血液。0、5、4和24小时后，两组之间仅在总蛋白和血清白蛋白方面存在显著差异。低分子量感染相关蛋白α-1-抗胰蛋白酶、免疫球蛋白G和抗凝血酶III，以及高分子量蛋白免疫球蛋白M、血浆纤连蛋白和α-2-巨球蛋白在两组之间任何时候均无显著差异。得出的结论是，明胶作为血浆代用品不会损害血浆纤连蛋白对网状内皮系统的调理作用。
