Lackner F X, Graninger W, Khosropour R
Eur J Anaesthesiol. 1985 Dec;2(4):407-17.
Approximately 25% of blood was replaced by either hydroxyethyl starch (mol. wt 450,000), dextran (mol. wt 60,000), or 5% plasma protein solution, 24 h prior to a surgical intervention. Twenty-four adult patients were studied and haematocrit, total protein, plasma albumin, alpha-1-antitrypsin, IgG, IgM, antithrombin III, fibronectin and alpha-2-macroglobulin were determined. The resulting blood concentrations suggest that the various replacement solutions exert only a dilutional effect upon the proteins studied. Furthermore, there is no difference regarding the course of the various infection-related proteins whether plasma protein solution or synthetic colloids are used for blood replacement. The decrease of the studied proteins during the study period does not exceed 35% of the control value. This is not considered to be a clinically significant reduction and levels of infection-related proteins were not dangerously low.
在手术干预前24小时，用羟乙基淀粉（分子量450,000）、右旋糖酐（分子量60,000）或5%血浆蛋白溶液替代了约25%的血液。对24名成年患者进行了研究，并测定了血细胞比容、总蛋白、血浆白蛋白、α-1-抗胰蛋白酶、IgG、IgM、抗凝血酶III、纤连蛋白和α-2-巨球蛋白。所得血液浓度表明，各种替代溶液对所研究的蛋白质仅产生稀释作用。此外，无论使用血浆蛋白溶液还是合成胶体进行血液置换，各种感染相关蛋白的变化过程均无差异。研究期间所研究蛋白质的减少不超过对照值的35%。这在临床上不被认为是显著降低，且感染相关蛋白水平也没有低到危险程度。
