Shen Xiao-Ling, Li Zhuo-Yi, Li Qing, Wang Kai
Department of Women Health Care, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361005, People's Republic of China.
Department of Aristogenesis, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361005, People's Republic of China.
Int J Womens Health. 2024 Jul 29;16:1285-1291. doi: 10.2147/IJWH.S468086. eCollection 2024.
To verify whether there is lower incidence of adverse pregnancy outcomes after high-intensity focused ultrasound (HIFU) treatment than loop electrosurgical excision procedure (LEEP) in young women of childbearing age.
This retrospective cohort study enrolled 46 patients treated with HIFU and 46 patients treated with LEEP. To compare the differences between the two groups, Fisher's exact test or the Kruskal-Wallis (K-W/H) test was used in the univariate analysis, while the logistic regression method was applied for further verification.
Basic characteristics showed no differences between the two groups (P > 0.05) except for parity (P < 0.001). Preterm birth rates were 6.52% and 0.00% in patients with cervical high-grade squamous intraepithelial lesions (HSIL) treated with LEEP and HIFU, respectively. The incidence rates of premature rupture of membranes (PROM) were respectively 15.22% and 21.74% in the two groups. There was no significant difference in pregnancy outcomes between the two groups (P > 0.05).
This study is the first to compare the pregnancy outcomes of patients with cervical HSIL who treated with LEEP and HIFU procedures. Both HIFU treatment and LEEP are available options for patients of reproductive age with cervical HSIL. Therefore, it is necessary to conduct prospective single-center or multicenter randomized controlled studies.
验证在育龄期年轻女性中，高强度聚焦超声（HIFU）治疗后不良妊娠结局的发生率是否低于环形电切术（LEEP）。
这项回顾性队列研究纳入了46例接受HIFU治疗的患者和46例接受LEEP治疗的患者。为比较两组之间的差异，单因素分析采用Fisher精确检验或Kruskal-Wallis（K-W/H）检验，进一步验证采用逻辑回归方法。
除产次外（P<0.001），两组的基本特征无差异（P>0.05）。接受LEEP和HIFU治疗的宫颈高级别鳞状上皮内病变（HSIL）患者的早产率分别为6.52%和0.00%。两组的胎膜早破（PROM）发生率分别为15.22%和21.74%。两组的妊娠结局无显著差异（P>0.05）。
本研究首次比较了接受LEEP和HIFU治疗的宫颈HSIL患者的妊娠结局。对于患有宫颈HSIL的育龄期患者，HIFU治疗和LEEP都是可行的选择。因此，有必要进行前瞻性单中心或多中心随机对照研究。
