Farooq Muhammad Umar, Dovzhenko Alexey P, Zairov Rustem R, Abyzbekova Gulmira, Harb Moussab, Arkook Bassim, Akylbekov Nurgali, Tapalova Anipa, Makhlouf Mohamed M
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
A. M. Butlerov Institute of Chemistry, Kazan Federal University, 1/29 Lobachevskogo str., Kazan 420008, Russian Federation.
ACS Omega. 2024 Jul 17;9(30):33033-33043. doi: 10.1021/acsomega.4c04134. eCollection 2024 Jul 30.
Chronic diseases, notably cancer, pose a significant global threat to human life. Oncologists and medical professionals addressing malignancies confront challenges such as toxicity and multidrug resistance. To tackle these issues, the focus has shifted toward the employment of multifunctional colloidal gold nanoparticles. This study aims to design pH-sensitive doxorubicin-loaded gold nanoparticles using polyvinylpyrrolidone. The cytotoxic efficacy of the designed gold nanoarchitecture and its doxorubicin counterpart was assessed in an in vitro model using the HeLa cell. In comparison to the free drug, experimental evaluations showed that the gold nanoarchitecture outperformed significantly lower unspecific drug leaching and efficiently delivered the payload in a controlled manner, boosting the chemotherapy outcomes. This work opens a streamlined approach for engineering gold nanoarchitecture that could be further expanded to incorporate other therapeutics and/or functional moieties that require optimized controlled delivery, offering a one-size-fits-all solution and paving the revolutionary adjustments to healthcare procedures.
慢性病，尤其是癌症，对全球人类生命构成重大威胁。治疗恶性肿瘤的肿瘤学家和医学专业人员面临着毒性和多药耐药性等挑战。为解决这些问题，重点已转向使用多功能胶体金纳米颗粒。本研究旨在使用聚乙烯吡咯烷酮设计对pH敏感的载有阿霉素的金纳米颗粒。在体外模型中使用HeLa细胞评估了所设计的金纳米结构及其阿霉素对应物的细胞毒性功效。与游离药物相比，实验评估表明，金纳米结构的非特异性药物渗漏显著更低，并且以可控方式有效递送了有效载荷，提高了化疗效果。这项工作为工程化金纳米结构开辟了一条简化途径，该途径可进一步扩展以纳入其他需要优化控制递送的治疗剂和/或功能部分，提供一种通用解决方案，并为医疗程序带来革命性变革。
