Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China.
Centre for Alcohol Policy Research, School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.
Eat Weight Disord. 2022 Oct;27(7):2425-2434. doi: 10.1007/s40519-021-01347-6. Epub 2022 Mar 1.
Previous studies show inconsistent associations between niacin supplementation and diabetes mellitus (DM) in high-risk population, but little is known about the relationship between dietary intake of niacin and DM in the generation population. Our study aimed to explore the associations of dietary niacin intake with the risk of DM in the United States (US) adult population.
These data were derived from the National Health and Nutrition Examination Survey (NHANES) 2003-2018 of 35,606 individuals aged 20 years or older. Niacin intake and food sources were measured by two 24-h dietary recall interviews. The diagnosis of DM was established according to the American Diabetes Association (ADA) criteria. Binary logistic regression and restricted cubic spline models were applied to evaluate the association of dietary niacin intake and DM.
Among the 35,606 individuals, the prevalence of DM was 11.47%. The full-adjusted odds ratio(aOR) of DM was 1.27(95%CI 1.06-1.52) for quartile (Q) 4 v. Q1 of dietary niacin intake. In the dose-response analysis, the shape of the association of niacin intake with the risk of DM was approximately J-shaped (non-linear, p < 0.05). Energy-adjusted niacin of 26.08 mg/day was the optimal cut-off value for predicting DM.
High dietary niacin intake was positively associated with DM among US adults.
Level V: Opinions of authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.
先前的研究表明，烟酸补充剂与高危人群中的糖尿病（DM）之间的关联并不一致，但关于一般人群中烟酸的饮食摄入量与 DM 之间的关系知之甚少。我们的研究旨在探讨美国（US）成年人群中饮食烟酸摄入量与 DM 风险之间的关联。
这些数据来自于 2003-2018 年的全国健康和营养检查调查（NHANES），涉及 35606 名年龄在 20 岁或以上的个体。烟酸的摄入量和来源通过两次 24 小时饮食回忆访谈进行测量。DM 的诊断根据美国糖尿病协会（ADA）标准确定。应用二项逻辑回归和限制三次样条模型评估饮食烟酸摄入与 DM 的关联。
在 35606 名个体中，DM 的患病率为 11.47%。全调整比值比（aOR）显示，烟酸摄入量四分位（Q）4 与 Q1 相比，DM 的比值为 1.27（95%CI 1.06-1.52）。在剂量反应分析中，烟酸摄入与 DM 风险之间的关联呈近似 J 形（非线性，p<0.05）。能量调整后的烟酸摄入量为 26.08mg/天是预测 DM 的最佳截断值。
美国成年人中，高饮食烟酸摄入量与 DM 呈正相关。
五级：基于描述性研究、叙述性综述、临床经验或专家委员会报告的权威意见。
