• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

中国百日咳病例和死亡人数上升:当前趋势和临床解决方案。

Rising pertussis cases and deaths in China: current trends and clinical solutions.

机构信息

Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics, Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, People's Republic of China.

出版信息

Emerg Microbes Infect. 2024 Dec;13(1):2389086. doi: 10.1080/22221751.2024.2389086. Epub 2024 Aug 21.

DOI:10.1080/22221751.2024.2389086
PMID:39101270
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11340210/
Abstract

Pertussis, an acute respiratory infection caused by Bordetella pertussis, has recently experienced a dramatic increase in incidence and associated deaths in China, drawing significant clinical attention. This article retrospectively analyzes national data on pertussis incidence and mortality from 2010 to 2024, exploring potential factors contributing to this trend. It also discusses strategies for enhancing vaccination programs, improving early diagnosis and treatment, and optimizing the clinical management of high-risk infants, with the aim of addressing the challenges posed by the current pertussis epidemic.

摘要

百日咳是由百日咳博德特氏菌引起的急性呼吸道传染病,近期在中国的发病率和相关死亡率急剧上升,引起了临床的高度关注。本文回顾性分析了 2010 年至 2024 年中国百日咳的发病率和死亡率数据,探讨了导致这一趋势的潜在因素。还讨论了加强疫苗接种计划、提高早期诊断和治疗水平以及优化高危婴儿临床管理的策略,旨在应对当前百日咳流行带来的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/11340210/8b006d0cc00b/TEMI_A_2389086_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/11340210/8b006d0cc00b/TEMI_A_2389086_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6193/11340210/8b006d0cc00b/TEMI_A_2389086_F0001_OC.jpg

相似文献

1
Rising pertussis cases and deaths in China: current trends and clinical solutions.中国百日咳病例和死亡人数上升:当前趋势和临床解决方案。
Emerg Microbes Infect. 2024 Dec;13(1):2389086. doi: 10.1080/22221751.2024.2389086. Epub 2024 Aug 21.
2
Pertussis upsurge, age shift and vaccine escape post-COVID-19 caused by ptxP3 macrolide-resistant Bordetella pertussis MT28 clone in China.中国 ptxP3 大环内酯类耐药博德特氏菌 MT28 克隆引起的 COVID-19 后百日咳疫情抬头、年龄偏移和疫苗逃逸。
Clin Microbiol Infect. 2024 Nov;30(11):1439-1446. doi: 10.1016/j.cmi.2024.08.016. Epub 2024 Aug 28.
3
Genetic Variation of Bordetella pertussis in Austria.奥地利百日咳博德特氏菌的基因变异
PLoS One. 2015 Jul 16;10(7):e0132623. doi: 10.1371/journal.pone.0132623. eCollection 2015.
4
Molecular epidemiology of Bordetella pertussis and analysis of vaccine antigen genes from clinical isolates from Shenzhen, China.中国深圳临床分离株百日咳博德特氏菌的分子流行病学和疫苗抗原基因分析。
Ann Clin Microbiol Antimicrob. 2021 Aug 18;20(1):53. doi: 10.1186/s12941-021-00458-3.
5
fim3-24/ptxP-3 genotype is associated to whooping cough outbreak in Brazilian Midwest: The selection of Bordetella pertussis strains driven by vaccine immunization.fim3-24/ptxP-3 基因型与巴西中西部百日咳爆发有关:疫苗免疫驱动的百日咳博德特氏菌菌株选择。
Infect Genet Evol. 2024 Jul;121:105599. doi: 10.1016/j.meegid.2024.105599. Epub 2024 Apr 26.
6
Neonatal pertussis, cocooning and maternal immunization.新生儿百日咳、围裹式预防策略与母体免疫
Expert Rev Vaccines. 2014 Sep;13(9):1107-14. doi: 10.1586/14760584.2014.944509. Epub 2014 Jul 30.
7
The global prevalence ptxP3 lineage of Bordetella pertussis was rare in young children with the co-purified aPV vaccination: a 5 years retrospective study.伴同纯化百日咳疫苗(aPV)接种,博德特氏菌 ptxP3 系在伴有 Co-纯化 百日咳疫苗(aPV)接种的幼儿中罕见:一项 5 年回顾性研究。
BMC Infect Dis. 2020 Aug 19;20(1):615. doi: 10.1186/s12879-020-05332-9.
8
High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014-2016.2014-2016 年中国大陆地区大环内酯类耐药百日咳博德特氏菌流行率高及 ptxP1 基因型占主导地位。
Emerg Infect Dis. 2019 Dec;25(12):2205-2214. doi: 10.3201/eid2512.181836.
9
Global resurgence of pertussis: A perspective from China.百日咳在全球死灰复燃:来自中国的观察。
J Infect. 2024 Nov;89(5):106289. doi: 10.1016/j.jinf.2024.106289. Epub 2024 Sep 30.
10
Challenges of interpreting epidemiologic surveillance pertussis data with changing diagnostic and immunization practices: the case of the state of São Paulo, Brazil.改变诊断和免疫实践对解释流行病情报百日咳数据的挑战:以巴西圣保罗州为例。
BMC Infect Dis. 2018 Mar 13;18(1):126. doi: 10.1186/s12879-018-3004-1.

引用本文的文献

1
Molecular epidemiology and genomic features of Bordetella pertussis in Tianjin, China, 2023.2023年中国天津百日咳博德特氏菌的分子流行病学及基因组特征
BMC Microbiol. 2025 Aug 23;25(1):534. doi: 10.1186/s12866-025-04276-x.
2
Global, regional, and national burdens of pertussis among adults: a systematic analysis of age-specific trends using Global Burden of Diseases 2021 data.成人百日咳的全球、区域和国家负担:利用《2021年全球疾病负担》数据对特定年龄趋势进行的系统分析。
Infect Dis Poverty. 2025 Aug 11;14(1):85. doi: 10.1186/s40249-025-01355-z.
3
The impact of COVID-19 pandemic on the etiological spectrum of respiratory infections in children.

本文引用的文献

1
Unraveling the resurgence of pertussis: Insights into epidemiology and global health strategies.解读百日咳的再度流行:对流行病学和全球卫生策略的见解
Pulmonology. 2024 Nov-Dec;30(6):503-505. doi: 10.1016/j.pulmoe.2024.04.009. Epub 2024 May 16.
2
Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis.中国人群中针对百日咳毒素 IgG 抗体的血清流行率:系统评价和荟萃分析。
Hum Vaccin Immunother. 2024 Dec 31;20(1):2341454. doi: 10.1080/21645515.2024.2341454. Epub 2024 May 2.
3
Whooping cough rises sharply in UK and Europe.
新冠疫情对儿童呼吸道感染病因谱的影响。
Eur J Clin Microbiol Infect Dis. 2025 Jul 31. doi: 10.1007/s10096-025-05222-5.
4
[Potential impact of adjusting immunization procedure for diphtheria-tetanus-pertussis vaccine on pertussis in clinical practice].调整白喉-破伤风-百日咳疫苗免疫程序对临床实践中百日咳的潜在影响
Zhongguo Dang Dai Er Ke Za Zhi. 2025 Jul 15;27(7):786-791. doi: 10.7499/j.issn.1008-8830.2501077.
5
Pertussis in the Post-COVID-19 Era: Resurgence, Diagnosis, and Management.新冠疫情后时代的百日咳:卷土重来、诊断与管理
Infect Chemother. 2025 Mar;57(1):13-30. doi: 10.3947/ic.2024.0117.
6
infection activates the type I interferon signaling pathway to exacerbate respiratory tract inflammatory response.感染激活I型干扰素信号通路,加剧呼吸道炎症反应。
Front Immunol. 2025 Mar 7;16:1521970. doi: 10.3389/fimmu.2025.1521970. eCollection 2025.
7
Real-World Effectiveness of 3 Types of Acellular Pertussis Vaccines Among Children Aged 3 Months-16 Years in Lu'an, China: A Matched Case-Control Study.中国六安3个月至16岁儿童中3种无细胞百日咳疫苗的真实世界有效性:一项匹配病例对照研究
Open Forum Infect Dis. 2025 Feb 10;12(2):ofaf082. doi: 10.1093/ofid/ofaf082. eCollection 2025 Feb.
8
Sources and clinical characteristics of infant pertussis in China: increasing contribution of siblings.中国婴幼儿百日咳的来源及临床特征:兄弟姐妹的影响日益增加。
BMC Infect Dis. 2025 Feb 10;25(1):198. doi: 10.1186/s12879-025-10536-y.
9
Resurgence of Pertussis in the Gyeongnam Region of South Korea in 2023 and 2024.2023年和2024年韩国庆南地区百日咳疫情的再度出现。
Vaccines (Basel). 2024 Nov 8;12(11):1261. doi: 10.3390/vaccines12111261.
百日咳在英国和欧洲急剧上升。
BMJ. 2024 Apr 2;385:q736. doi: 10.1136/bmj.q736.
4
Domination of an emerging erythromycin-resistant ptxP3 Bordetella pertussis clone in Shanghai, China.中国上海新兴红霉素耐药 ptxP3 博德特氏菌克隆的主导地位。
Int J Antimicrob Agents. 2023 Jul;62(1):106835. doi: 10.1016/j.ijantimicag.2023.106835. Epub 2023 Apr 30.
5
Macrolide Resistance in : Current Situation and Future Challenges.大环内酯类耐药性:现状与未来挑战
Antibiotics (Basel). 2022 Nov 7;11(11):1570. doi: 10.3390/antibiotics11111570.
6
A Cross-Sectional Study Revealing the Emergence of Erythromycin-Resistant Carrying Alleles in China.一项揭示中国红霉素耐药携带等位基因出现情况的横断面研究。
Front Microbiol. 2022 Jul 18;13:901617. doi: 10.3389/fmicb.2022.901617. eCollection 2022.
7
Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis.呼吸道合胞病毒感染对因百日咳住院患儿的临床影响。
BMC Infect Dis. 2021 Feb 9;21(1):161. doi: 10.1186/s12879-021-05863-9.
8
Bordetella pertussis is a common pathogen in infants hospitalized for acute lower respiratory tract infection during the winter season.百日咳博德特氏菌是冬季因急性下呼吸道感染住院的婴儿的常见病原体。
J Infect Chemother. 2021 Mar;27(3):497-502. doi: 10.1016/j.jiac.2020.11.002. Epub 2020 Dec 7.
9
Multicenter Evaluation of BioFire FilmArray Respiratory Panel 2 for Detection of Viruses and Bacteria in Nasopharyngeal Swab Samples.多中心评价生物梅里埃 FilmArray 呼吸道Panel 2 检测鼻咽拭子样本中病毒和细菌
J Clin Microbiol. 2018 May 25;56(6). doi: 10.1128/JCM.01945-17. Print 2018 Jun.
10
Risk factors of ICU or high dependency requirements amongst hospitalized pediatric pertussis cases: A 10 year retrospective series, Singapore.住院儿童百日咳病例入住 ICU 或高依赖病房的风险因素:10 年回顾性系列研究,新加坡。
Vaccine. 2017 Nov 7;35(47):6422-6428. doi: 10.1016/j.vaccine.2017.09.085. Epub 2017 Oct 9.