Department of Laboratory Medicine, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.
Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
J Infect. 2024 Nov;89(5):106289. doi: 10.1016/j.jinf.2024.106289. Epub 2024 Sep 30.
Pertussis (or whooping cough) is a highly infectious acute respiratory disease primarily caused by Bordetella pertussis, which is also one of the most important causes of infant death worldwide. The widespread use of vaccines has greatly reduced the morbidity and mortality of pertussis. However, since the 1980s, in a number of countries with high vaccine coverage, the incidence of pertussis has risen again after remaining low for many years, with outbreaks even occurring in some areas. The peak onset of pertussis is shifting from infancy to adolescence, and adolescence is becoming the main source of infection for infants. Despite the increasing incidence of pertussis, serological findings suggest that the true prevalence of the disease may be significantly underestimated. Therefore, in this narrative review, we summarize the pathogenic process and immune characteristics of bacteria, the diagnosis and treatment of diseases, as well as vaccination and prevalence of pertussis at home and abroad, and attempt to analyze the causes and influencing factors of pertussis resurgence and summarize some prevention and control strategies to assist in improving the understanding of pertussis and preventing unexpected outbreaks.
百日咳（或百日咳）是一种高度传染性的急性呼吸道疾病，主要由百日咳博德特氏菌引起，也是全球导致婴儿死亡的最重要原因之一。疫苗的广泛使用大大降低了百日咳的发病率和死亡率。然而，自 20 世纪 80 年代以来，在一些疫苗覆盖率较高的国家，百日咳的发病率在多年保持较低水平后再次上升，一些地区甚至出现了疫情。百日咳的发病高峰从婴儿期转移到了青春期，青春期成为了婴儿感染的主要来源。尽管百日咳的发病率不断上升，但血清学研究结果表明，该病的实际流行率可能被严重低估。因此，在本叙述性综述中，我们总结了细菌的致病过程和免疫特征、疾病的诊断和治疗、国内外的疫苗接种和流行情况，并尝试分析百日咳卷土重来的原因和影响因素，总结了一些防控策略，以帮助提高对百日咳的认识，预防意外爆发。
