Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Xinjiang Clinical Research Center for Dermatology and Venereology, Urumqi, China.
J Med Virol. 2024 Aug;96(8):e29794. doi: 10.1002/jmv.29794.
Human herpesvirus 8 (HHV-8) infection shows obvious regional and ethnic differences. Although studies have shown that these differences may be associated with lipid metabolism, to date, no large-scale studies have explored this. This study explored the seropositivity rate of HHV-8 among 2516 residents from 10 regions of northwest China and then the correlates of HHV-8 infection with lipid profile. The HHV-8 serological positivity rate was 15.6% among all residents. The HHV-8 seroprevalence ranged 11.2-27.6% among different ethnicities. Across different BMI levels, the positive rates of HHV-8 were 27.6%, 16.9%, and 13.6% for a BMI < 18.5, 18.5-24.9, and ≥25, respectively. HHV-8 seropositivity rate was lower for hypertensive people (12.6%) than for non-hypertensive people (16.7%). Univariate logistic regression analyses revealed that age, hypertension, systolic blood pressure, BMI, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) significantly correlated with HHV-8 seropositivity (p < 0.05). Multivariate logistic regression analysis after adjusting for confounding factors showed that HDL-C (odds ratio [OR]: 0.132, 95% confidence interval [CI], 0.082-0.212; p < 0.001) and BMI (OR: 0.959, 95% CI 0.933-0.986; p = 0.003) were associated with HHV-8 seropositivity. Subgroup analyses concerning ethnicity, sex, or age demonstrated a consistent relationship with HDL-C. The results of HHV-8 seropositivity and BMI were inconsistent in the subgroups. However, Spearman's correlation analysis between HHV-8 serum antibody titer and HDL-C levels showed no linear relationship among HHV-8 seropositive individuals (ρ = -0.080, p = 0.058). HHV-8 serum antibody titers were also not significantly correlated with BMI (ρ = -0.015, p = 0.381). Low HDL-C levels may be an independent risk factor for HHV-8 infection, but there is no significant correlation between HDL-C levels and HHV-8 antibody titers.
人类疱疹病毒 8 型（HHV-8）感染存在明显的地域和种族差异。尽管研究表明这些差异可能与脂代谢有关，但迄今为止，尚未有大规模研究对此进行探索。本研究探讨了中国西北 10 个地区 2516 名居民的 HHV-8 血清阳性率，并探讨了 HHV-8 感染与血脂谱的相关性。所有居民的 HHV-8 血清阳性率为 15.6%。不同种族的 HHV-8 血清流行率为 11.2-27.6%。在不同 BMI 水平下，HHV-8 的阳性率分别为 BMI<18.5、18.5-24.9 和≥25 的 27.6%、16.9%和 13.6%。高血压人群（12.6%）的 HHV-8 血清阳性率低于非高血压人群（16.7%）。单因素 logistic 回归分析显示，年龄、高血压、收缩压、BMI、总胆固醇和高密度脂蛋白胆固醇（HDL-C）与 HHV-8 血清阳性率显著相关（p<0.05）。在调整混杂因素后进行多因素 logistic 回归分析显示，HDL-C（比值比 [OR]：0.132，95%置信区间 [CI]：0.082-0.212；p<0.001）和 BMI（OR：0.959，95%CI 0.933-0.986；p=0.003）与 HHV-8 血清阳性率相关。按种族、性别或年龄进行的亚组分析显示与 HDL-C 呈一致关系。在亚组中，HHV-8 血清阳性率和 BMI 的结果不一致。然而，在 HHV-8 血清阳性个体中，HHV-8 血清抗体滴度与 HDL-C 水平之间的 Spearman 相关分析显示没有线性关系（ρ=-0.080，p=0.058）。HHV-8 血清抗体滴度与 BMI 也没有显著相关性（ρ=-0.015，p=0.381）。低 HDL-C 水平可能是 HHV-8 感染的独立危险因素，但 HDL-C 水平与 HHV-8 抗体滴度之间无显著相关性。
