Rodrillo Karl Angelo M, Costa Diego M, Viana Sarah F C, Shahbazi Hasti, Augusti Rodinei, Ifa Demian R
Department of Chemistry, York University, Toronto, Ontario, Canada.
Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
J Forensic Sci. 2024 Nov;69(6):2209-2221. doi: 10.1111/1556-4029.15592. Epub 2024 Aug 5.
In this work, we employed a new ambient ionization mass spectrometry technique, sandpaper spray mass spectrometry (SPS-MS), as an efficient tool to analyze pills and tablets of pharmaceutical formulations. The following samples were analyzed: regulators of blood pressure, cholesterol, and diabetes, and drugs for the treatment of erectile dysfunction (ED). Additionally, a hard candy of Cannabis sativa containing Δ9-tetrahydrocannabinol (Δ-THC) and its related isomer cannabidiol (CBD) was also evaluated. The surfaces of the samples, without any prior treatment, were sanded onto triangular-cut sandpaper, and full MS scans (and MS/MS) were acquired in both positive and negative ionization modes. SPS-MS (and MS/MS) allowed for prompt detection of the active pharmaceutical ingredients (APIs) in each formulation. Other components of the formulations, added as excipients, were also tentatively identified. The results described herein indicate that the SPS-MS technique can be applied to fast screening of pills and tablets being potentially used as an efficient tool to detect counterfeit pharmaceutical and illicit products, a current issue of increasing concern.
在本研究中，我们采用了一种新的常压电离质谱技术——砂纸喷雾质谱法（SPS-MS），作为分析药物制剂药丸和片剂的有效工具。对以下样品进行了分析：血压调节剂、胆固醇调节剂、糖尿病药物以及治疗勃起功能障碍（ED）的药物。此外，还对一种含有Δ9-四氢大麻酚（Δ-THC）及其相关异构体大麻二酚（CBD）的大麻硬糖进行了评估。未经任何预处理的样品表面被打磨到三角形切割的砂纸上，并在正离子和负离子模式下进行全质谱扫描（和串联质谱）。SPS-MS（和串联质谱）能够迅速检测出每种制剂中的活性药物成分（API）。还初步鉴定了作为辅料添加的制剂中的其他成分。本文所述结果表明，SPS-MS技术可应用于药丸和片剂的快速筛查，有望作为检测假冒药品和非法产品的有效工具，这是当前一个日益受到关注的问题。
