C-POLAR Technologies Inc., West Vancouver, British Columbia, Canada.
Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, China.
Microbiol Spectr. 2024 Sep 3;12(9):e0409723. doi: 10.1128/spectrum.04097-23. Epub 2024 Aug 5.
Infection control measures to prevent viral and bacterial infection spread are critical to maintaining a healthy environment. Pathogens such as viruses and pyogenic bacteria can cause infectious complications. Viruses such as SARS-CoV-2 are known to spread through the aerosol route and on fomite surfaces, lasting for a prolonged time in the environment. Developing technologies to mitigate the spread of pathogens through airborne routes and on surfaces is critical, especially for patients at high risk for infectious complications. Multifunctional coatings with a broad capacity to bind pathogens that result in inactivation can disrupt infectious spread through aerosol and inanimate surface spread. This study uses C-POLAR, a proprietary cationic, polyamine, organic polymer with a charged, dielectric property coated onto air filtration material and textiles. Using both SARS-CoV-2 live viral particles and bovine coronavirus models, C-POLAR-treated material shows a dramatic 2-log reduction in circulating viral inoculum. This reduction is consistent in a static room model, indicating simple airflow through a static C-POLAR hanging can capture significant airborne particles. Finally, Gram-positive and Gram-negative bacteria are applied to C-POLAR textiles using a viability indicator to demonstrate eradication on fomite surfaces. These data suggest that a cationic polymer surface can capture and eradicate human pathogens, potentially interrupting the infectious spread for a more resilient environment.
Infection control is critical for maintaining a healthy home, work, and hospital environment. We test a cationic polymer capable of capturing and eradicating viral and bacterial pathogens by applying the polymer to the air filtration material and textiles. The data suggest that the simple addition of cationic material can result in the improvement of an infectious resilient environment against viral and bacterial pathogens.
为了维持健康的环境，预防病毒和细菌感染传播的感染控制措施至关重要。病原体，如病毒和化脓性细菌，会引起传染性并发症。已知 SARS-CoV-2 等病毒通过气溶胶途径和污染物表面传播，在环境中持续时间较长。开发技术以减轻通过空气传播途径和表面传播的病原体的传播至关重要，特别是对于有感染性并发症高风险的患者。具有广泛结合病原体能力并导致失活的多功能涂层可以阻止通过气溶胶和无生命表面传播的感染扩散。本研究使用 C-POLAR，这是一种专有的阳离子、多胺、带有带电介电特性的有机聚合物，涂覆在空气过滤材料和纺织品上。使用 SARS-CoV-2 活病毒颗粒和牛冠状病毒模型，C-POLAR 处理的材料显示出循环病毒接种物减少 2 个对数。这种减少在静态房间模型中是一致的，表明通过静态 C-POLAR 悬挂的简单空气流可以捕获大量空气传播颗粒。最后，使用生存力指示剂将革兰氏阳性和革兰氏阴性细菌应用于 C-POLAR 纺织品上，以证明在污染物表面的根除。这些数据表明，阳离子聚合物表面可以捕获和根除人类病原体，可能会中断更具弹性的感染传播。
感染控制对于维持健康的家庭、工作和医院环境至关重要。我们通过将聚合物应用于空气过滤材料和纺织品来测试一种能够捕获和根除病毒和细菌病原体的阳离子聚合物。数据表明，简单添加阳离子材料可以改善对病毒和细菌病原体具有弹性的感染环境。
