Liu Haitao, Wang Yaqing, Zhang Xu, Zhang Min, Wang Peng, Shang Jing, Li Zhongqiang, Gong Likun, Guo Jiabin, Sun Wei, Pi Jingbo, Li Xianliang, Ding Wei, Wang Dianbing, Li Zhongyu, Zhang Jingzhong, Wang Lan, Geng Xingchao, Yang Ruifu, Zhou Pingkun, Tang Wanjin, Zhang Xian'en, Chen Chunying, Yang Shengli, Qin Jianhua
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
University of Science and Technology of China, Hefei, China.
Cell Regen. 2024 Aug 5;13(1):16. doi: 10.1186/s13619-024-00198-7.
Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accelerate the innovation in life sciences including disease modeling, drug development, and precision medicine. However, due to the lack of standards in their definition, structural design, cell source, model construction, and functional validation, a wide range of translational application of organs-on-chips remains a challenging. "Organs-on-chips: Intestine" is the first group standard on human intestine-on-a-chip in China, jointly agreed and released by the experts from the Chinese Society of Biotechnology on 29th April 2024. This standard specifies the scope, terminology, definitions, technical requirements, detection methods, and quality control in building the human intestinal model on a chip. The publication of this group standard will guide the institutional establishment, acceptance and execution of proper practical protocols and accelerate the international standardization of intestine-on-a-chip for translational applications.
器官芯片是一种微生理系统，能够复制人体器官的关键功能，并加速生命科学领域的创新，包括疾病建模、药物开发和精准医学。然而，由于在其定义、结构设计、细胞来源、模型构建和功能验证方面缺乏标准，器官芯片的广泛转化应用仍然具有挑战性。《器官芯片：肠道》是中国首个关于肠道芯片的团体标准，由中国生物工程学会专家于2024年4月29日共同商定并发布。本标准规定了在芯片上构建人体肠道模型的范围、术语、定义、技术要求、检测方法和质量控制。该团体标准的发布将指导适当实践方案的制度建立、验收和执行，并加速肠道芯片在转化应用方面的国际标准化。
