Department of Ophthalmology, The Jikei University School of Medicine, Nishi-shimbashi, Tokyo, Japan.
Department of Ophthalmology, Machida Municipal Hospital, Machida, Tokyo, Japan.
Transl Vis Sci Technol. 2024 Aug 1;13(8):9. doi: 10.1167/tvst.13.8.9.
We aimed to preliminarily compare the glaucoma detection accuracy of a head-mounted binocular visual perimeter "imo" screening program (ISP) with that of frequency doubling technology (FDT).
This multicenter, diagnostic accuracy study based on prospectively collected data included 76 non-glaucoma (including pre-perimetric glaucoma) eyes and 92 glaucomatous eyes from patients visiting two hospitals. Patients underwent ISP and FDT (C-20-1 screening program) on the same day. Diagnostic efficacy was evaluated using receiver operating characteristic curves and areas under the curve (AUCs). In addition, we compared the ISP and FDT testing times.
AUC values for ISP versus FDT were as follows: (1) mild-stage glaucoma (mean deviation [MD] > -6 dB), 0.82 (95% confidence interval [CI], 0.75-0.88) versus 0.76 (95% CI, 0.68-0.83); moderate-stage glaucoma (-6 dB ≥ MD ≥ -12 dB), 0.98 (95% CI, 0.95-1.00) versus 0.96 (95% CI, 0.93-1.00); and advanced-stage glaucoma (-12 dB > MD), 1.00 (95% CI, 1.00-1.00) versus 0.99 (95% CI, 0.98-1.00). In addition, mild-stage glaucoma was classified into two stages (MD > -3 D) and (-3 D ≥ MD > -6 D). AUC values were 0.81 (95% CI, 0.73-0.88) versus 0.76 (95% CI, 0.68-0.84) for MD > -3 D and 0.86 (95% CI, 0.77-0.94) versus 0.73 (95% CI, 0.61-0.86) for -3 D ≥ MD > -6 D. The testing time for the ISP was significantly shorter than that of FDT for all glaucoma stages (P < 0.001).
The ISP demonstrates non-inferiority in detecting glaucoma and has a shorter testing time compared with FDT. These findings provide evidence for applied further studies on large-scale population-based glaucoma screening.
Our study provides a non-inferior and quicker glaucoma screening than existing tools.
本研究旨在初步比较头戴式双目视觉周边检查仪“imo”筛查程序（ISP）与频域加倍技术（FDT）检测青光眼的准确性。
本研究为基于前瞻性收集数据的多中心诊断准确性研究，共纳入来自 2 家医院就诊的 76 例非青光眼（包括前期青光眼）眼和 92 例青光眼眼。患者于同一天接受 ISP 和 FDT（C-20-1 筛查程序）检查。使用受试者工作特征曲线和曲线下面积（AUCs）评估诊断效果。此外，我们还比较了 ISP 和 FDT 的检测时间。
ISP 与 FDT 的 AUC 值如下：（1）轻度青光眼（平均偏差 [MD] > -6 dB）为 0.82（95%置信区间 [CI]，0.75-0.88）vs 0.76（95% CI，0.68-0.83）；中度青光眼（-6 dB≥MD≥-12 dB）为 0.98（95% CI，0.95-1.00）vs 0.96（95% CI，0.93-1.00）；晚期青光眼（-12 dB>MD）为 1.00（95% CI，1.00-1.00）vs 0.99（95% CI，0.98-1.00）。此外，将轻度青光眼分为两个阶段（MD > -3 dB）和（-3 dB≥MD > -6 dB）。MD > -3 dB 的 AUC 值为 0.81（95% CI，0.73-0.88），-3 dB≥MD > -6 dB 的 AUC 值为 0.76（95% CI，0.68-0.84）。ISP 的检测时间对于所有青光眼阶段均显著短于 FDT（P < 0.001）。
与 FDT 相比，ISP 在检测青光眼方面具有非劣效性，且检测时间更短。这些发现为在大规模基于人群的青光眼筛查中进一步开展研究提供了证据。
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