van Furth R
Comp Immunol Microbiol Infect Dis. 1985;8(2):205-11. doi: 10.1016/0147-9571(85)90045-1.
The majority of the resident macrophages in non-inflamed organs and serous cavities derive from circulating monocytes, but a small proportion originate from immature mononuclear phagocytes that only divide once in the tissues and originate from the bone marrow as well. During an acute inflammation the number of circulating monocytes increases, and a large proportion of these cells migrate to the site of inflammation and differentiate into exudate macrophages. The monocyte production during an acute inflammation is controlled by humoral factor, FIM, which is a protein that is synthesized and secreted by macrophages at the site of inflammation.
在非炎症器官和浆膜腔中，大多数驻留巨噬细胞来源于循环单核细胞，但一小部分起源于未成熟的单核吞噬细胞，这些细胞仅在组织中分裂一次，同样也起源于骨髓。在急性炎症期间，循环单核细胞数量增加，其中很大一部分细胞迁移到炎症部位并分化为渗出性巨噬细胞。急性炎症期间单核细胞的产生受体液因子FIM控制，FIM是一种由炎症部位的巨噬细胞合成和分泌的蛋白质。
