van Furth R
Haematol Blood Transfus. 1981;27:3-10. doi: 10.1007/978-3-642-81696-3_1.
The present communication discusses the origin of monocytes and macrophages and gives new mathematical approach to the analysis of results obtained in studies on cell kinetics. It has been shown that the great majority of the macrophages derive from circulating monocytes, whereas the remainder arise by division of immature mononuclear phagocytes in the tissues. However, these dividing cells too originate in the bone marrow and have recently arrived in the tissues. The turnover time of tissue macrophages appears to be of the order of 1 to 5 weeks, which is shorter than had previously been calculated. During an inflammatory response, monocyte production in the bone marrow is regulated by humoral factors that stimulate or inhibit the mitotic activity of promonocytes and their precursors. Whether such factors are also present during the normal steady state is not yet certain.
本通讯讨论了单核细胞和巨噬细胞的起源，并给出了分析细胞动力学研究结果的新数学方法。已表明，绝大多数巨噬细胞来源于循环中的单核细胞，而其余部分则由组织中未成熟单核吞噬细胞的分裂产生。然而，这些分裂细胞也起源于骨髓，并且最近才到达组织中。组织巨噬细胞的更新时间似乎在1至5周的范围内，这比之前计算的要短。在炎症反应期间，骨髓中单核细胞的产生受体液因子调节，这些因子刺激或抑制前单核细胞及其前体的有丝分裂活性。在正常稳态期间是否也存在此类因子尚不确定。
