Anesthesiology Department, Shanghai DeltaHealth Hospital, No.109 Xule Road, Qingpu District, Shanghai, 201700, China.
J Cardiothorac Surg. 2024 Aug 5;19(1):480. doi: 10.1186/s13019-024-02956-9.
Human fibrinogen (FIB) has been clinically proven to be considerably effective for the treatment of postoperative bleeding, with reported cases of allergic reactions to human FIB being rare. Here, we report a case of an anaphylactic shock in 27-year-old patients with rheumatic heart valve disease who received a human FIB infusion during mitral valve replacement, aortic valve replacement, and tricuspid valve-shaping surgery. The patients showed generalised profuse sweating, a barely noticeable skin rash, faint pulse, systolic pressure < 50 mmHg, and a heart rate of 71 beats/min. We share insights from a case of severe allergy to human FIB infusion during cardiac surgery, through which we have gained experience in the processes of diagnosing and treating. This report aims to provide a preliminary summary of the characteristics of this case to serve as a reference for fellow clinicians.
人纤维蛋白原（FIB）已被临床证明在治疗术后出血方面非常有效，据报道，对人 FIB 发生过敏反应的情况很少见。在这里，我们报告了一例 27 岁风湿性心脏瓣膜病患者在二尖瓣置换术、主动脉瓣置换术和三尖瓣成形术中接受人 FIB 输注后发生过敏性休克的病例。患者表现为全身性大量出汗、几乎察觉不到的皮疹、脉搏微弱、收缩压<50mmHg，心率 71 次/分。我们分享了一例心脏手术中严重人纤维蛋白原输注过敏的病例见解，从中我们获得了诊断和治疗的经验。本报告旨在初步总结该病例的特点，为临床医生提供参考。
