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New insights on the role of chondroitin sulfate proteoglycans in neural stem cell-mediated repair in spinal cord injury.

作者信息

Hosseini Seyed Mojtaba, Karimi-Abdolrezaee Soheila

机构信息

Department of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada (Hosseini SM, Karimi-Abdolrezaee S).

Manitoba Multiple Sclerosis Research Center, Winnipeg, MB, Canada (Hosseini SM, Karimi-Abdolrezaee S).

出版信息

Neural Regen Res. 2025 Jun 1;20(6):1699-1700. doi: 10.4103/NRR.NRR-D-24-00378. Epub 2024 Jul 10.

DOI:10.4103/NRR.NRR-D-24-00378
PMID:39104100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688555/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3d/11688555/07fe280235d1/NRR-20-1699-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3d/11688555/07fe280235d1/NRR-20-1699-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3d/11688555/07fe280235d1/NRR-20-1699-g001.jpg

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本文引用的文献

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Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances.神经干细胞疗法治疗脊髓损伤修复：近期临床前和临床进展的更新。
Brain. 2024 Mar 1;147(3):766-793. doi: 10.1093/brain/awad392.
2
Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury.硫酸软骨素蛋白聚糖通过 TLR4 防止免疫细胞表型转化和炎症消退在脊髓损伤的啮齿动物模型中。
Nat Commun. 2022 May 25;13(1):2933. doi: 10.1038/s41467-022-30467-5.
3
Suppressing CSPG/LAR/PTPσ Axis Facilitates Neuronal Replacement and Synaptogenesis by Human Neural Precursor Grafts and Improves Recovery after Spinal Cord Injury.
抑制 CSPG/LAR/PTPσ 轴促进人神经前体细胞移植物的神经元替代和突触形成，并改善脊髓损伤后的恢复。
J Neurosci. 2022 Apr 13;42(15):3096-3121. doi: 10.1523/JNEUROSCI.2177-21.2022. Epub 2022 Mar 7.
4
Transplanting neural progenitor cells to restore connectivity after spinal cord injury.将神经祖细胞移植以恢复脊髓损伤后的连接性。
Nat Rev Neurosci. 2020 Jul;21(7):366-383. doi: 10.1038/s41583-020-0314-2. Epub 2020 Jun 9.
5
Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms.创伤性脊髓损伤：病理生理学、模型及急性损伤机制概述
Front Neurol. 2019 Mar 22;10:282. doi: 10.3389/fneur.2019.00282. eCollection 2019.
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LAR and PTPσ receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury.LAR 和 PTPσ 受体是脊髓损伤中少突胶质细胞发生和少突胶质细胞完整性的负调节因子。
Glia. 2019 Jan;67(1):125-145. doi: 10.1002/glia.23533. Epub 2018 Nov 5.
7
Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury.通过 LAR 和 PTPσ 受体扰乱软骨素硫酸盐蛋白聚糖信号转导可促进脊髓损伤后的有益炎症反应。
J Neuroinflammation. 2018 Mar 20;15(1):90. doi: 10.1186/s12974-018-1128-2.
8
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Stem Cells. 2015 Aug;33(8):2550-63. doi: 10.1002/stem.1979. Epub 2015 May 12.
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Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury.蛋白聚糖受体 PTPσ 的调节促进脊髓损伤后的恢复。
Nature. 2015 Feb 19;518(7539):404-8. doi: 10.1038/nature13974. Epub 2014 Dec 3.
10
Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization.蛋白酪氨酸磷酸酶 PTPδ、PTPσ 和 LAR：突触组织的突触前枢纽。
Trends Neurosci. 2013 Sep;36(9):522-34. doi: 10.1016/j.tins.2013.06.002. Epub 2013 Jul 5.