Wu Yong-Yao, Li Jun-Yuan, Xia Qiao-Jing, Gao Yi-Yi, Zhang Chao, Xu Peng-Jie, Liu Jiang, Zhang Hao-Jie, Yu Ri-Zhen
Department of Nephrology, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang Province, 315099, People's Republic of China.
Urology & Nephrology Center, Department of Nephrology, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, 310014, People's Republic of China.
J Multidiscip Healthc. 2024 Aug 1;17:3743-3751. doi: 10.2147/JMDH.S469900. eCollection 2024.
Sarcopenia is more common in maintenance hemodialysis (MHD) patients, and the aim of this study is to analyze the risk factors associated with sarcopenia in MHD patients, along with its correlation to emotional status and quality of life.
This is a cross-sectional cohort study. A total of 111 MHD patients who were treated in the Department of Nephrology of our hospital were selected as the study subjects by convenience sampling. The quality of life and emotional status were evaluated by health survey scale (SF-36), self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Regression analysis was used to explore the influencing factors of sarcopenia. Correlation analysis was used to investigate the correlation between sarcopenia and quality of life and emotional status.
The prevalence of sarcopenia was 59.8%. The results showed that age, gender, body mass index (BMI), dialysis time, economic status, marital status and pre-dialysis creatinine were significant factors affecting the development of sarcopenia in hemodialysis patients (<0.05). The SF-36 total score was significantly lower in the sarcopenia group (72.05±12.28 vs 78.03±10.55) than in the non-sarcopenia group, but the anxiety scale score (52.97±4.67 vs 36.2±3.36) and depression scale score (57.67±4.58 vs 38.71±3.77) were significantly higher than those in the non-sarcopenia group (p< 0.001). Correlation analysis showed that sarcopenia was positively correlated with SAS and SDS scores and negatively correlated with SF-36 total score (p < 0.05).
The risk of sarcopenia was higher among MHD patients who were older, male, single, with a longer MHD duration, lower economic status, lower BMI, comorbid diabetes and lower levels of creatinine.
肌肉减少症在维持性血液透析（MHD）患者中更为常见，本研究旨在分析MHD患者肌肉减少症的相关危险因素，及其与情绪状态和生活质量的相关性。
这是一项横断面队列研究。通过便利抽样，选取我院肾内科接受治疗的111例MHD患者作为研究对象。采用健康调查量表（SF-36）、自评焦虑量表（SAS）和自评抑郁量表（SDS）评估生活质量和情绪状态。采用回归分析探讨肌肉减少症的影响因素。采用相关性分析研究肌肉减少症与生活质量和情绪状态之间的相关性。
肌肉减少症的患病率为59.8%。结果显示，年龄、性别、体重指数（BMI）、透析时间、经济状况、婚姻状况和透析前肌酐是影响血液透析患者肌肉减少症发生发展的显著因素（<0.05）。肌肉减少症组的SF-36总分（72.05±12.28 vs 78.03±10.55）显著低于非肌肉减少症组，但焦虑量表评分（52.97±4.67 vs 36.2±3.36）和抑郁量表评分（57.67±4.58 vs 38.71±3.77）显著高于非肌肉减少症组（p<0.001）。相关性分析显示，肌肉减少症与SAS和SDS评分呈正相关，与SF-36总分呈负相关（p<0.05）。
年龄较大、男性、单身、MHD病程较长、经济状况较低、BMI较低、合并糖尿病且肌酐水平较低的MHD患者发生肌肉减少症的风险较高。
