Palacio Ariana, Cebrian Karla Medrano, Majores Michael, Uerlich Manfred, Bierhoff Erhard, Bonness Sonja, Reinhold Uwe
MVZ Dermatologisches Zentrum Bonn Bonn Germany.
Heinz-Werner-Seifert Institut für Dermatopathologie Bonn Germany.
Skin Health Dis. 2024 Apr 1;4(4):e378. doi: 10.1002/ski2.378. eCollection 2024 Aug.
Rowell Syndrome is a rare entity combining erythema exudativum multiforme (EEM) and lupus erythematosus (LE). Zeitouni et al. redefined Rowell Syndrome's diagnostic criteria. Major criteria include: (1) LE (systemic, discoid or subacute cutaneous), (2) EEM-like skin lesions and (3) speckled pattern of antinuclear antibodies. Minor criteria comprise: (1) chilblains, (2) positive anti-SSA/Ro or anti-SSB/La antibodies and (3) positive rheumatoid factor. The diagnosis is achieved when all major criteria and at least one minor criterion are present. Prognosis and treatment regimens are those of EEM and LE, with reported good response to oral cortisone, azathioprine, cyclosporine, dapsone, antimalarials and methotrexate. We present a case of Rowell Syndrome in a young adult after a herpes simplex type 1 infection and unprotected sun exposure, with good response to both topical corticosteroids and calcineurin-inhibitors.
罗威尔综合征是一种罕见的疾病，它合并了多形性渗出性红斑（EEM）和红斑狼疮（LE）。泽图尼等人重新定义了罗威尔综合征的诊断标准。主要标准包括：（1）红斑狼疮（系统性、盘状或亚急性皮肤型），（2）类似多形性渗出性红斑的皮肤损害，以及（3）抗核抗体斑点型。次要标准包括：（1）冻疮，（2）抗SSA/Ro或抗SSB/La抗体阳性，以及（3）类风湿因子阳性。当所有主要标准和至少一项次要标准都存在时即可确诊。预后和治疗方案与多形性渗出性红斑和红斑狼疮相同，据报道口服可的松、硫唑嘌呤、环孢素、氨苯砜、抗疟药和甲氨蝶呤有良好反应。我们报告一例年轻成人在单纯疱疹病毒1型感染和无防护日光暴露后发生的罗威尔综合征病例，该病例对局部皮质类固醇和钙调神经磷酸酶抑制剂均有良好反应。
