Yu Tim, Bruce Stephen, Nguyen Diep, Patel Anika, MacElwee Mark
Department of Internal Medicine, Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, USA.
Department of Internal Medicine, Creighton University School of Medicine, St. Joseph's Hospital and Medical Center, Phoenix, USA.
Cureus. 2024 Jul 6;16(7):e63977. doi: 10.7759/cureus.63977. eCollection 2024 Jul.
The clinical course and treatment of hypercalcemia from a granulomatous disease in the setting of an infectious etiology, namely disseminated coccidioidomycosis, remains incompletely understood. The mechanism and treatment of hypercalcemia have been documented in most granulomatous disorders, with sarcoidosis being the most well-understood so far. We discuss a case of a patient with a recent diagnosis of disseminated coccidioidomycosis who presented with hypercalcemia despite adequate infection control. The treatment course involved combinatorial-calcitonin, low-dose bisphosphonates, and corticosteroids, which led to a favorable outcome.
在感染性病因（即播散性球孢子菌病）背景下，肉芽肿性疾病所致高钙血症的临床病程及治疗仍未完全明确。多数肉芽肿性疾病中高钙血症的机制及治疗已有文献记载，其中结节病是目前了解最为透彻的。我们讨论一例近期诊断为播散性球孢子菌病的患者，尽管感染得到了充分控制，但仍出现了高钙血症。治疗过程包括联合使用降钙素、低剂量双膦酸盐和皮质类固醇，最终取得了良好的效果。
