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介孔硅纳米颗粒:肺癌管理中一种多功能的载体平台。

Mesoporous silica nanoparticles: a versatile carrier platform in lung cancer management.

机构信息

Chitkara College of Pharmacy, Chitkara University, Punjab, 140401, India.

Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104,India.

出版信息

Nanomedicine (Lond). 2024 Jun 20;19(15):1331-1346. doi: 10.1080/17435889.2024.2348438. Epub 2024 May 20.

Abstract

Mesoporous silica nanoparticles (MSNPs) are inorganic nanoparticles that have been comprehensively investigated and are intended to deliver therapeutic agents. MSNPs have revolutionized the therapy for various conditions, especially cancer and infectious diseases. In this article, the viability of MSNPs' administration for lung cancer therapy has been reviewed. However, certain challenges lay ahead in the successful translation such as toxicology, immunology, large-scale production, and regulatory matters have made it extremely difficult to translate such discoveries from the bench to the bedside. This review highlights recent developments, characteristics, mechanism of action and customization for targeted delivery. This review also covers the most recent data that sheds light on MSNPs' extraordinary therapeutic potential in fighting lung cancer as well as future hurdles.

摘要

介孔硅纳米颗粒(MSNPs)是一种无机纳米颗粒,已被广泛研究并旨在递送治疗剂。MSNPs 彻底改变了各种疾病的治疗方法,尤其是癌症和传染病。在本文中,我们回顾了 MSNPs 用于肺癌治疗的可行性。然而,在成功转化方面仍面临着一些挑战,例如毒理学、免疫学、大规模生产和监管问题,这使得将这些发现从实验室转化到临床变得极其困难。本综述重点介绍了最近的进展、特点、作用机制和靶向递药的定制。本综述还涵盖了最新的数据,这些数据阐明了 MSNPs 在治疗肺癌方面的非凡治疗潜力以及未来的障碍。

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